Blood flow velocity comparison in the eye capillaries and postcapillary venules between normal pregnant and non-pregnant women.
Blood flow velocity
Blood volume flow
Capillaries
Diameter
Hemodynamics
Human conjunctiva
Human microcirculation
Normal pregnancy
Postcapillary venules
Slit-lamp biomicroscopy
Journal
Microvascular research
ISSN: 1095-9319
Titre abrégé: Microvasc Res
Pays: United States
ID NLM: 0165035
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
07
06
2019
revised:
27
08
2019
accepted:
11
09
2019
pubmed:
16
9
2019
medline:
21
7
2020
entrez:
16
9
2019
Statut:
ppublish
Résumé
There is no consensus on how much and at what diameters the blood flow velocity changes in the female microcirculation during normal pregnancy. A non-contact, digital slit-lamp biomicroscopy system was used to measure axial blood velocity (Vax) and diameter (D) in the conjunctival microcirculation of 28 normal non-pregnant women (Control Group), 17 women in the first semester of their normal pregnancy (Group 1) and 16 women in the third trimester of their normal pregnancy (Group 2). Blood volume flow (Q) was estimated from Vax and D. Microvessels were classified as "capillaries" (CAP) with D < 9 μm, "postcapillary venules of size 1" (PC1) with 9 ≤ D < 14 μm and "postcapillary venules of size 2" (PC2) with 14 ≤ D ≤ 24 μm. The women groups did not differ significantly in age, diastolic and systolic pressure and diameter of each size. Taking as baseline the capillary Vax of 0.51 mm/s of the Control Group, there was a statistically significant (p < 0.001) increase to 0.74 mm/s (45%) in Group 1 and to 0.95 mm/s (86%) in Group 2. This significant Vax increase in capillaries (CAP) was a consistent finding irrespective of the exact vessel size cut-off value for discriminating CAP from PC1. There was no statistical difference in Vax among groups at postcapillary venules of size 2 (PC2). Statistical conclusions for blood volume flows were similar to velocities. Normal pregnancy increases significantly axial blood velocity (Vax) in capillaries (CAP) with diameter <9 μm.
Sections du résumé
BACKGROUND
There is no consensus on how much and at what diameters the blood flow velocity changes in the female microcirculation during normal pregnancy.
METHODS
A non-contact, digital slit-lamp biomicroscopy system was used to measure axial blood velocity (Vax) and diameter (D) in the conjunctival microcirculation of 28 normal non-pregnant women (Control Group), 17 women in the first semester of their normal pregnancy (Group 1) and 16 women in the third trimester of their normal pregnancy (Group 2). Blood volume flow (Q) was estimated from Vax and D. Microvessels were classified as "capillaries" (CAP) with D < 9 μm, "postcapillary venules of size 1" (PC1) with 9 ≤ D < 14 μm and "postcapillary venules of size 2" (PC2) with 14 ≤ D ≤ 24 μm.
RESULTS
The women groups did not differ significantly in age, diastolic and systolic pressure and diameter of each size. Taking as baseline the capillary Vax of 0.51 mm/s of the Control Group, there was a statistically significant (p < 0.001) increase to 0.74 mm/s (45%) in Group 1 and to 0.95 mm/s (86%) in Group 2. This significant Vax increase in capillaries (CAP) was a consistent finding irrespective of the exact vessel size cut-off value for discriminating CAP from PC1. There was no statistical difference in Vax among groups at postcapillary venules of size 2 (PC2). Statistical conclusions for blood volume flows were similar to velocities.
CONCLUSIONS
Normal pregnancy increases significantly axial blood velocity (Vax) in capillaries (CAP) with diameter <9 μm.
Identifiants
pubmed: 31521542
pii: S0026-2862(19)30139-6
doi: 10.1016/j.mvr.2019.103926
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103926Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.