NCoR1: Putting the Brakes on the Dendritic Cell Immune Tolerance.
Immune Response
Immunology
Molecular Mechanism of Gene Regulation
Transcriptomics
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
27 Sep 2019
27 Sep 2019
Historique:
received:
27
02
2019
revised:
19
06
2019
accepted:
13
08
2019
pubmed:
16
9
2019
medline:
16
9
2019
entrez:
16
9
2019
Statut:
ppublish
Résumé
Understanding the mechanisms fine-tuning immunogenic versus tolerogenic balance in dendritic cells (DCs) is of high importance for therapeutic approaches. We found that NCoR1-mediated direct repression of the tolerogenic program in conventional DCs is essential for induction of an optimal immunogenic response. NCoR1 depletion upregulated a wide variety of tolerogenic genes in activated DCs, which consequently resulted in increased frequency of FoxP3
Identifiants
pubmed: 31522122
pii: S2589-0042(19)30302-5
doi: 10.1016/j.isci.2019.08.024
pmc: PMC6744395
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
996-1011Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
Références
Nat Rev Immunol. 2010 Mar;10(3):170-81
pubmed: 20154735
Front Immunol. 2012 Nov 07;3:331
pubmed: 23162549
Oncotarget. 2015 Dec 22;6(41):43267-80
pubmed: 26657115
J Exp Med. 2017 Jan;214(1):125-142
pubmed: 27913566
Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10729-34
pubmed: 16807294
Front Immunol. 2018 Feb 28;9:333
pubmed: 29541071
Immunity. 2011 Aug 26;35(2):153-5
pubmed: 21867923
J Immunol. 2004 May 15;172(10):6047-56
pubmed: 15128788
Cell Metab. 2012 Apr 4;15(4):554-62
pubmed: 22465074
CNS Neurosci Ther. 2013 Apr;19(4):269-77
pubmed: 23521914
J Immunol. 2016 Mar 15;196(6):2561-71
pubmed: 26851220
Aging (Albany NY). 2016 Jun;8(6):1223-35
pubmed: 27244900
Immunol Lett. 2009 Jun 30;125(1):7-14
pubmed: 19446579
Trends Immunol. 2012 Apr;33(4):181-9
pubmed: 22398370
Front Immunol. 2018 Aug 24;9:1912
pubmed: 30197645
Arthritis Res Ther. 2005;7(3):100-10
pubmed: 15899058
Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5931-6
pubmed: 20231464
Front Immunol. 2017 Jun 22;8:726
pubmed: 28690613
Immunol Cell Biol. 2013 Oct;91(9):543-4
pubmed: 24108273
J Exp Med. 2008 Jan 21;205(1):13-7
pubmed: 18195077
Eur J Immunol. 2014 May;44(5):1422-32
pubmed: 24643576
Genes Dev. 2013 Apr 15;27(8):819-35
pubmed: 23630073
Nat Rev Immunol. 2003 Dec;3(12):984-93
pubmed: 14647480
Eur J Immunol. 2011 May;41(5):1420-34
pubmed: 21469094
Mol Endocrinol. 1998 Oct;12(10):1567-81
pubmed: 9773980
J Immunol. 2009 Aug 15;183(4):2435-43
pubmed: 19625647
Cell. 2010 Mar 19;140(6):805-20
pubmed: 20303872
Nucleic Acids Res. 2011 Mar;39(6):e35
pubmed: 21177645
Eur J Immunol. 2014 Apr;44(4):1143-55
pubmed: 24338929
Immune Netw. 2016 Feb;16(1):52-60
pubmed: 26937232
Front Immunol. 2015 Oct 19;6:528
pubmed: 26539195
Cell. 2002 Feb 22;108(4):465-74
pubmed: 11909518
Nat Immunol. 2010 Dec;11(12):1093-101
pubmed: 20953201
Front Immunol. 2014 Sep 25;5:461
pubmed: 25309543
J Immunol. 2008 May 1;180(9):5771-7
pubmed: 18424693
FEBS Lett. 2011 May 6;585(9):1331-7
pubmed: 21492741
Nat Rev Immunol. 2013 Jun;13(6):453-60
pubmed: 23681101
Nat Immunol. 2012 Dec;13(12):1162-70
pubmed: 23086447
Mol Cell. 2008 Mar 28;29(6):755-66
pubmed: 18374649
Cell Biosci. 2011 May 24;1(1):20
pubmed: 21711933
Transpl Int. 2017 Aug;30(8):754-764
pubmed: 27864897
Cell. 2013 Sep 26;155(1):200-214
pubmed: 24074869
J Immunol. 2010 Nov 15;185(10):5953-61
pubmed: 20944000
Cytokine. 2007 Sep;39(3):184-91
pubmed: 17822917
Genes Dev. 2009 Mar 15;23(6):681-93
pubmed: 19299558
Mol Cell Biol. 2005 Feb;25(3):1113-23
pubmed: 15657437
J Immunol. 2000 Nov 1;165(9):5227-37
pubmed: 11046056
Cold Spring Harb Perspect Biol. 2010 Apr;2(4):a000257
pubmed: 20452937
Mol Cell. 2012 May 11;46(3):335-50
pubmed: 22521691
Front Immunol. 2018 Nov 13;9:2604
pubmed: 30483264
Mol Cell. 2012 Sep 14;47(5):810-22
pubmed: 22940246
Immunol Cell Biol. 2014 May-Jun;92(5):436-48
pubmed: 24492801
Eur J Immunol. 2011 Feb;41(2):413-24
pubmed: 21268011
Curr Immunol Rev. 2005 Jun;1(2):119-137
pubmed: 21037949
Nat Rev Immunol. 2004 Oct;4(10):762-74
pubmed: 15459668
J Leukoc Biol. 2015 Nov;98(5):689-702
pubmed: 26059829
Biochim Biophys Acta. 2015 Feb;1852(2):365-78
pubmed: 24807060
Cell. 2011 Nov 11;147(4):827-39
pubmed: 22078881
Trends Immunol. 2009 Aug;30(8):383-91
pubmed: 19643665
Front Immunol. 2015 Nov 09;6:569
pubmed: 26617604
Immunity. 2011 Jul 22;35(1):82-96
pubmed: 21723156
F1000Res. 2015 Dec 17;4:
pubmed: 26918147
Mol Cell. 2009 Jul 10;35(1):48-57
pubmed: 19595715
Eur J Immunol. 2011 Feb;41(2):286-90
pubmed: 21267998
Novartis Found Symp. 2006;279:101-9; discussion 109-13, 216-9
pubmed: 17278389
J Allergy Clin Immunol. 2014 Oct;134(4):944-954.e8
pubmed: 25051954
Clin Exp Immunol. 2017 Jan;187(1):113-123
pubmed: 27667787
J Immunol. 2004 Jul 1;173(1):531-41
pubmed: 15210814
Immunology. 2008 Mar;123(3):326-38
pubmed: 17983439
Nat Immunol. 2015 Oct;16(10):1060-8
pubmed: 26343536
Cell Metab. 2014 Jul 1;20(1):26-40
pubmed: 24794975
J Immunol. 2003 Mar 15;170(6):3263-72
pubmed: 12626585
J Biol Chem. 2005 Apr 8;280(14):13600-5
pubmed: 15691842