Safety and pharmacodynamics of anti-CD2 monoclonal antibody treatment in cynomolgus macaques - an experimental study.
anti-CD2
induction
large animal models
monoclonal antibody
tolerance
Journal
Transplant international : official journal of the European Society for Organ Transplantation
ISSN: 1432-2277
Titre abrégé: Transpl Int
Pays: Switzerland
ID NLM: 8908516
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
22
03
2019
revised:
25
05
2019
accepted:
09
09
2019
pubmed:
17
9
2019
medline:
28
5
2021
entrez:
17
9
2019
Statut:
ppublish
Résumé
Anti-CD2 treatment provides targeted immunomodulatory properties that have demonstrated clinical usefulness to condition the immune system and to treat transplant rejection. The treatment is species-specific due to structural CD2 antigen differences between nonhuman primates and humans. Herein, we report the safety profile and efficacy of two modifications of the same anti-CD2 monoclonal antibody in cynomolgus macaques. Twelve subjects received one i.v. anti-CD2 (of rat or rhesus type) dose each, range 1-4 mg/kg, and were followed for 1-7 days. Treatment effects were evaluated with flow cytometry on peripheral blood and histopathological evaluation of secondary lymphoid organs. In vitro inhibitory activity on primary MHC disparate mixed lymphocyte reactions (MLRs) was determined. Upon anti-CD2 treatment, CD4
Identifiants
pubmed: 31523849
doi: 10.1111/tri.13524
pmc: PMC7017722
mid: NIHMS1552573
doi:
Substances chimiques
Antibodies, Monoclonal
0
CD2 Antigens
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
98-107Subventions
Organisme : NIAID NIH HHS
ID : U24 AI126683
Pays : United States
Organisme : NIH Nonhuman Primate Reagent Resource
ID : R24OD010976
Organisme : NIDDK NIH HHS
ID : R01 DK064819
Pays : United States
Organisme : Herbert Irving Comprehensive Cancer Center Flow Cytometry Shared Resources funded in part through Center Grant
ID : P30CA013696
Organisme : NIH Nonhuman Primate Reagent Resource
ID : U24AI126683
Organisme : NCATS NIH HHS
ID : UL1 TR001873
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063608
Pays : United States
Organisme : NIH HHS
ID : UL1TR001873
Pays : United States
Organisme : NIH HHS
ID : R24 OD010976
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : Diabetes and Endocrinology Research Center Flow Core Facility funded in part through Center Grant
ID : 5P30DK063608
Organisme : NIAID NIH HHS
ID : R56 AI122332
Pays : United States
Informations de copyright
© 2019 Steunstichting ESOT.
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