Glymphatics Visualization after Focused Ultrasound-Induced Blood-Brain Barrier Opening in Humans.
Journal
Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
04
10
2018
revised:
13
09
2019
accepted:
13
09
2019
pubmed:
17
9
2019
medline:
9
4
2020
entrez:
17
9
2019
Statut:
ppublish
Résumé
It is currently unclear whether the glymphatic system, a brain-wide interstitial fluid-cerebrospinal fluid exchange described in rodents, exists in humans. Focal blood-brain barrier disruption using magnetic resonance-guided focused ultrasound allows parenchymal penetration of gadobutrol contrast, creating an opportunity to study glymphatics in vivo noninvasively. We describe patterns of contrast distribution in the perivascular space, subarachnoid space, and space surrounding large veins draining toward the dural sinuses on fluid-attenuated inversion recovery in subjects with Alzheimer disease and amyotrophic lateral sclerosis. This is the first evidence suggesting glymphatic efflux persists in humans. It's relevance to proteinopathies and drug delivery is discussed. ANN NEUROL 2019;86:975-980.
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
975-980Subventions
Organisme : ALS Society of Canada
Pays : International
Organisme : Focused Ultrasound Foundation
Pays : International
Organisme : W. Garfield Weston Foundation
Pays : International
Informations de copyright
© 2019 American Neurological Association.
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