Immune checkpoint blockade in small cell lung cancer.

Animals Antineoplastic Agents, Immunological / therapeutic use B7-H1 Antigen / antagonists & inhibitors CTLA-4 Antigen / antagonists & inhibitors Humans Immunotherapy / methods Lung Neoplasms / drug therapy Small Cell Lung Carcinoma / drug therapy
Atezolizumab Immunotherapy Ipilimumab Nivolumab Pembrolizumab Small cell lung cancer

Journal

Lung cancer (Amsterdam, Netherlands)
ISSN: 1872-8332
Titre abrégé: Lung Cancer
Pays: Ireland
ID NLM: 8800805

Informations de publication

Date de publication:
11 2019
Historique:
received: 06 06 2019
revised: 14 08 2019
accepted: 21 08 2019
pubmed: 17 9 2019
medline: 29 7 2020
entrez: 17 9 2019
Statut: ppublish

Résumé

Despite the highly immunogenic potential of small cell lung cancer (SCLC), progress in evaluating the therapeutic value of immune checkpoint agents has lagged behind that of non-small cell lung cancer. Results from a number of phase I-III clinical trials that specifically address the use of anti-PD-1, anti-PD-L1 and anti-CTLA-4 agents in SCLC have now been reported. This review will focus on the available evidence for immune checkpoint blockade in SCLC and review current biomarker strategies with the aim of providing perspective and interpretation of this data for clinical practice.

Identifiants

DOI: 10.1016/j.lungcan.2019.08.024 PMID: 31525648
pubmed: 31525648
pii: S0169-5002(19)30625-7
doi: 10.1016/j.lungcan.2019.08.024
pii:
doi:

Substances chimiques

Antineoplastic Agents, Immunological 0
B7-H1 Antigen 0
CD274 protein, human 0
CTLA-4 Antigen 0
CTLA4 protein, human 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

31-37

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Rebecca Y Tay (RY)

Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.

David Heigener (D)

Helios Klinik Schleswig, Dept. of Pulmonology, Schleswig, Germany.

Martin Reck (M)

Lung Clinic Grosshansdorf, Airway Research Center North, German Center of Lung Research, Grosshansdorf, Germany.

Raffaele Califano (R)

Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom; Department of Medical Oncology, Manchester University NHS Foundation Trust, Manchester, United Kingdom; Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom. Electronic address: raffaele.califano@christie.nhs.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Immune checkpoint blockade in small cell lung cancer.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques immunologiques › Immune checkpoint blockade in small cell lung cancer.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD274 › Immune checkpoint blockade in small cell lung cancer.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigène CTLA-4 › Immune checkpoint blockade in small cell lung cancer.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Immune checkpoint blockade in small cell lung cancer.
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Immune checkpoint blockade in small cell lung cancer.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Immune checkpoint blockade in small cell lung cancer.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire à petites cellules › Immune checkpoint blockade in small cell lung cancer.