Divergent Synthesis of Methylene Lactone- and Methylene Lactam-Based Spiro Compounds: Utility of Amido-Functionalized γ-Hydroxylactam as a Precursor for Cytotoxic

Animals Antineoplastic Agents / chemical synthesis Cell Line, Tumor Cell Proliferation / drug effects Crystallography, X-Ray Drug Screening Assays, Antitumor Lactams / chemistry Lactones / chemistry Mice Models, Molecular Molecular Structure Spiro Compounds / chemical synthesis

Journal

The Journal of organic chemistry
ISSN: 1520-6904
Titre abrégé: J Org Chem
Pays: United States
ID NLM: 2985193R

Informations de publication

Date de publication:
04 10 2019
Historique:
pubmed: 19 9 2019
medline: 29 7 2020
entrez: 19 9 2019
Statut: ppublish

Résumé

Pharmaceutically attractive methylene lactone- and methylene lactam-based spiro compounds have been synthesized by employing amido-functionalized γ-hydroxylactam as a common intermediate. Development of a new route for bifurcated synthesis of two types of

Identifiants

DOI: 10.1021/acs.joc.9b02038 PMID: 31525925
pubmed: 31525925
doi: 10.1021/acs.joc.9b02038
doi:

Substances chimiques

Antineoplastic Agents 0
Lactams 0
Lactones 0
Spiro Compounds 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12532-12541

Auteurs

Tetsuya Sengoku (T)

Department of Applied Chemistry, Faculty of Engineering , Shizuoka University , 3-5-1 Johoku , Naka-ku, Hamamatsu 432-8561 , Japan.
ORCID: 0000-0002-5208-9460

Anna Shirai (A)

Department of Applied Chemistry, Faculty of Engineering , Shizuoka University , 3-5-1 Johoku , Naka-ku, Hamamatsu 432-8561 , Japan.

Ayaka Takano (A)

Department of Applied Chemistry, Faculty of Engineering , Shizuoka University , 3-5-1 Johoku , Naka-ku, Hamamatsu 432-8561 , Japan.

Toshiyasu Inuzuka (T)

Division of Instrumental Analysis, Life Science Research Center , Gifu University , 1-1 Yanagido , Gifu 501-1193 , Japan.

Masami Sakamoto (M)

Department of Applied Chemistry and Biotechnology, Graduate School of Engineering , Chiba University , 1-33 Yayoi-cho , Inage-ku, Chiba 263-8522 , Japan.
ORCID: 0000-0001-9489-2641

Masaki Takahashi (M)

Department of Applied Chemistry, Faculty of Engineering , Shizuoka University , 3-5-1 Johoku , Naka-ku, Hamamatsu 432-8561 , Japan.
ORCID: 0000-0001-6613-4173

Hidemi Yoda (H)

Department of Applied Chemistry, Faculty of Engineering , Shizuoka University , 3-5-1 Johoku , Naka-ku, Hamamatsu 432-8561 , Japan.
ORCID: 0000-0001-8843-6850

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Divergent Synthesis of Methylene Lactone- and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Divergent Synthesis of Methylene Lactone- and...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Divergent Synthesis of Methylene Lactone- and...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Divergent Synthesis of Methylene Lactone- and...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Divergent Synthesis of Methylene Lactone- and...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Divergent Synthesis of Methylene Lactone- and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Lactames › Divergent Synthesis of Methylene Lactone- and...
questionsmedicales.fr › Composés chimiques organiques › Lactones › Divergent Synthesis of Methylene Lactone- and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Divergent Synthesis of Methylene Lactone- and...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Divergent Synthesis of Methylene Lactone- and...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Divergent Synthesis of Methylene Lactone- and...
questionsmedicales.fr › Composés polycycliques › Spiranes › Divergent Synthesis of Methylene Lactone- and...