Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition.
Antigens, Viral, Tumor
/ genetics
Carcinoma, Merkel Cell
/ etiology
Cell Cycle
/ genetics
Cell Line, Tumor
Cell Lineage
/ genetics
Cell Transformation, Viral
Gene Knockdown Techniques
Humans
Keratinocytes
Merkel Cells
/ metabolism
Merkel cell polyomavirus
/ genetics
Neurites
/ metabolism
Neurons
/ metabolism
Phenotype
Polyomavirus Infections
/ complications
SOXB1 Transcription Factors
/ genetics
Tumor Virus Infections
/ complications
Atoh1
Merkel cell carcinoma
Merkel cell polyomavirus
Sox2
phenotypic conversion
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
01 10 2019
01 10 2019
Historique:
pubmed:
19
9
2019
medline:
31
3
2020
entrez:
19
9
2019
Statut:
ppublish
Résumé
Viral cancers show oncogene addiction to viral oncoproteins, which are required for survival and proliferation of the dedifferentiated cancer cell. Human Merkel cell carcinomas (MCCs) that harbor a clonally integrated Merkel cell polyomavirus (MCV) genome have low mutation burden and require viral T antigen expression for tumor growth. Here, we showed that MCV
Identifiants
pubmed: 31527246
pii: 1907154116
doi: 10.1073/pnas.1907154116
pmc: PMC6778204
doi:
Substances chimiques
Antigens, Viral, Tumor
0
SOX2 protein, human
0
SOXB1 Transcription Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20104-20114Subventions
Organisme : NCI NIH HHS
ID : P50 CA121973
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR063724
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA047904
Pays : United States
Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
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