Non-steroidal anti-inflammatory drugs use in older adults decreases risk of Alzheimer's disease mortality.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
07
05
2019
accepted:
02
09
2019
entrez:
19
9
2019
pubmed:
19
9
2019
medline:
7
3
2020
Statut:
epublish
Résumé
Alzheimer disease (AD) mortality risk in a large cohort of subjects treated or not with non-steroidal anti-inflammatory drugs (NSAIDs) is unknown. Our objective was to determine whether NSAIDs use is associated with decreased risk of AD mortality. In this prospective, population-based study (Neurological Disorders in Central Spain [NEDICES]) of 5,072 people without AD (aged 65 years and older), sociodemographic, comorbidity factors, and current medications were recorded at baseline. Community-dwelling older adults were followed for a median of 12.7 years, after which the death certificates of deceased participants were examined. 2,672 (52.7%) of 5,072 participants died, including 504 (18.9%) NSAIDs users and 2,168 (81.1%) non-users. Of the 2,672 deceased participants, 113 (4.2%) had AD as a cause of death (8 [1.6%] among NSAIDs users and 105 [4.8%] among non-users, chi-square = 10.70, p = 0.001). In an unadjusted Cox model, risk of AD mortality was decreased in NSAIDs users (hazard ratio [HR] for AD mortality = 0.35, 95% confidence interval [CI] 0.17-0.72, p = 0.004) when compared to non-users. After adjusting for numerous demographic factors and co-morbidities, the HR for AD mortality in NSAIDs users was 0.29, 95% CI 0.12-0.73, p = 0.009. Stratified analyses showed a significantly decreased risk of AD mortality with aspirin, whereas non-aspirin NSAIDs only showed a statistical trend toward significance in the adjusted Cox regression models. NSAIDs use was associated with 71% decreased risk of AD mortality in older adults. Our results support the hypothesis that NSAIDs use is a protective factor of developing AD.
Identifiants
pubmed: 31527913
doi: 10.1371/journal.pone.0222505
pii: PONE-D-19-12874
pmc: PMC6748568
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Banques de données
Dryad
['10.5061/dryad.91k8jr2']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0222505Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Mov Disord. 2003 Mar;18(3):267-74
pubmed: 12621629
Mov Disord. 2003 Apr;18(4):389-94
pubmed: 12671944
Neurology. 2004 Mar 9;62(5):734-41
pubmed: 15007123
Public Health. 2004 Sep;118(6):426-33
pubmed: 15313596
Neurology. 2006 Jan 10;66(1):69-74
pubmed: 16401849
Lancet. 2006 Feb 18;367(9510):606-17
pubmed: 16488805
J Neurol Sci. 2008 Jan 15;264(1-2):63-72
pubmed: 17727890
Brain. 2008 Mar;131(Pt 3):651-64
pubmed: 18292081
Rev Neurol. 2008 Apr 1-15;46(7):416-23
pubmed: 18389461
Neuroepidemiology. 2008;30(4):247-53
pubmed: 18515974
J Geriatr Psychiatry Neurol. 2009 Dec;22(4):246-55
pubmed: 19417217
J Clin Epidemiol. 2010 Feb;63(2):215-22
pubmed: 19473811
Expert Opin Investig Drugs. 2009 Aug;18(8):1147-68
pubmed: 19589092
Lancet. 1990 Apr 28;335(8696):1037
pubmed: 1970087
Aging (Albany NY). 2009 Feb 11;1(2):234-44
pubmed: 20157512
J Alzheimers Dis. 2010;21(1):95-102
pubmed: 20413854
J Neurol Neurosurg Psychiatry. 2010 Sep;81(9):997-1001
pubmed: 20547612
J Alzheimers Dis. 2010;22(1):159-70
pubmed: 20847410
J Alzheimers Dis. 2010;22(3):949-58
pubmed: 20858957
Arch Gen Psychiatry. 2012 Jan;69(1):98-106
pubmed: 22213792
Cochrane Database Syst Rev. 2012 Feb 15;(2):CD006378
pubmed: 22336816
J Neurochem. 2013 Jan;124(1):59-68
pubmed: 23083210
Neurology. 2013 Mar 12;80(11):1048-56
pubmed: 23390179
Neurology. 2013 Jul 2;81(1):60-6
pubmed: 23700331
J Alzheimers Dis. 2014;41(1):213-21
pubmed: 24583403
Neurology. 2014 Apr 22;82(16):1441-8
pubmed: 24719490
J Alzheimers Dis. 2015;44(2):385-96
pubmed: 25227314
Parkinsonism Relat Disord. 2015 Jun;21(6):622-8
pubmed: 25887487
ACS Chem Neurosci. 2016 Apr 20;7(4):454-63
pubmed: 26979823
Medicine (Baltimore). 2016 Aug;95(33):e4607
pubmed: 27537597
Comput Struct Biotechnol J. 2016 Oct 29;15:1-7
pubmed: 27872687
Cureus. 2017 Apr 8;9(4):e1144
pubmed: 28491485
J Alzheimers Dis. 2018;62(3):1219-1222
pubmed: 29103042
Curr Alzheimer Res. 2018;15(6):504-510
pubmed: 29283047
Front Aging Neurosci. 2018 Mar 28;10:83
pubmed: 29643804
Neurology. 2019 Apr 30;92(18):e2070-e2080
pubmed: 30952794
Cureus. 2019 May 8;11(5):e4620
pubmed: 31312547
Neurology. 1984 Jul;34(7):939-44
pubmed: 6610841
Acta Neurol Scand Suppl. 1996;165:18-24
pubmed: 8740985