Bridging the gap: Spinal cord fusion as a treatment of chronic spinal cord injury.
Electrical stimulation
GEMINI
polyethylene glycol
spinal cord fusion
spinal cord transection
Journal
Surgical neurology international
ISSN: 2229-5097
Titre abrégé: Surg Neurol Int
Pays: United States
ID NLM: 101535836
Informations de publication
Date de publication:
2019
2019
Historique:
received:
21
12
2018
accepted:
06
02
2019
entrez:
19
9
2019
pubmed:
19
9
2019
medline:
19
9
2019
Statut:
epublish
Résumé
Despite decades of animal experimentation, human translation with cell grafts, conduits, and other strategies has failed to cure patients with chronic spinal cord injury (SCI). Recent data show that motor deficits due to spinal cord transection in animal models can be reversed by local application of fusogens, such as Polyethylene glycol (PEG). Results proved superior at short term over all other treatments deployed in animal studies, opening the way to human trials. In particular, removal of the injured spinal cord segment followed by PEG fusion of the two ends along with vertebral osteotomy to shorten the spine holds the promise for a cure in many cases.
Identifiants
pubmed: 31528389
doi: 10.25259/SNI-19-2019
pii: SNI-10-51
pmc: PMC6743693
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
51Déclaration de conflit d'intérêts
There are no conflicts of interest.
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