Chitosan films for regenerative medicine: fabrication methods and mechanical characterization of nanostructured chitosan films.

Chitosan Microgratings Nanostructured surfaces Nerve regeneration Solvent casting

Journal

Biophysical reviews
ISSN: 1867-2450
Titre abrégé: Biophys Rev
Pays: Germany
ID NLM: 101498573

Informations de publication

Date de publication:
Oct 2019
Historique:
received: 23 07 2019
accepted: 02 09 2019
pubmed: 19 9 2019
medline: 19 9 2019
entrez: 19 9 2019
Statut: ppublish

Résumé

Regenerative medicine is continuously facing new challenges and it is searching for new biocompatible, green/natural polymer materials, possibly biodegradable and non-immunogenic. Moreover, the critical importance of the nano/microstructuring of surfaces is overall accepted for their full biocompatibility and in vitro/in vivo performances. Chitosan is emerging as a promising biopolymer for tissue engineering and its application can be further improved by exploiting its nano/microstructuration. Here, we report the state of the art of chitosan films and scaffolds nano/micro-structuration. We show that it is possible to obtain, by solvent casting, chitosan thin films with good mechanical properties and to structure them at the microscale and even nanoscale level, with resolutions down to 100 nm.

Identifiants

pubmed: 31529358
doi: 10.1007/s12551-019-00591-6
pii: 10.1007/s12551-019-00591-6
pmc: PMC6815298
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

807-815

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Auteurs

Alessia De Masi (A)

NEST, Scuola Normale Superiore, Piazza San Silvestro 12, 56127, Pisa, Italy.

Ilaria Tonazzini (I)

NEST, Istituto Nanoscienze-CNR, Piazza San Silvestro 12, 56127, Pisa, Italy. ilaria.tonazzini@sns.it.

Cecilia Masciullo (C)

NEST, Scuola Normale Superiore, Piazza San Silvestro 12, 56127, Pisa, Italy.

Roberta Mezzena (R)

NEST, Scuola Normale Superiore, Piazza San Silvestro 12, 56127, Pisa, Italy.

Federica Chiellini (F)

Department of Chemistry and Industrial Chemistry, University of Pisa, UdR INSTM PISA, Via G. Moruzzi 13, 56124, Pisa, Italy.

Dario Puppi (D)

Department of Chemistry and Industrial Chemistry, University of Pisa, UdR INSTM PISA, Via G. Moruzzi 13, 56124, Pisa, Italy.

Marco Cecchini (M)

NEST, Scuola Normale Superiore, Piazza San Silvestro 12, 56127, Pisa, Italy.
NEST, Istituto Nanoscienze-CNR, Piazza San Silvestro 12, 56127, Pisa, Italy.

Classifications MeSH