Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4
Adenosine Triphosphate
/ immunology
Animals
CD4-Positive T-Lymphocytes
/ immunology
Humans
Interferon-gamma
/ immunology
Mitochondria
/ immunology
Mitochondrial Proton-Translocating ATPases
/ immunology
Neoplasms
/ immunology
Oxygen Consumption
/ immunology
Phosphorylation
/ immunology
Signal Transduction
/ immunology
Smad Proteins
/ immunology
Transforming Growth Factor beta
/ blood
Tumor Microenvironment
/ immunology
Journal
Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400
Informations de publication
Date de publication:
17 09 2019
17 09 2019
Historique:
entrez:
19
9
2019
pubmed:
19
9
2019
medline:
11
8
2020
Statut:
epublish
Résumé
Transforming growth factor-β (TGF-β) is produced by tumors, and increased amounts of this cytokine in the tumor microenvironment and serum are associated with poor patient survival. TGF-β-mediated suppression of antitumor T cell responses contributes to tumor growth and survival. However, TGF-β also has tumor-suppressive activity; thus, dissecting cell type-specific molecular effects may inform therapeutic strategies targeting this cytokine. Here, using human peripheral and tumor-associated lymphocytes, we investigated how tumor-derived TGF-β suppresses a key antitumor function of CD4
Identifiants
pubmed: 31530731
pii: 12/599/eaav3334
doi: 10.1126/scisignal.aav3334
pii:
doi:
Substances chimiques
Smad Proteins
0
Transforming Growth Factor beta
0
Interferon-gamma
82115-62-6
Adenosine Triphosphate
8L70Q75FXE
Mitochondrial Proton-Translocating ATPases
EC 3.6.3.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.