Recovery of central memory and naive peripheral T cells in Follicular Lymphoma patients receiving rituximab-chemotherapy based regimen.
Aged
Antineoplastic Combined Chemotherapy Protocols
/ adverse effects
Biomarkers
Cyclophosphamide
Doxorubicin
Female
Humans
Immunity, Cellular
Immunologic Memory
/ drug effects
Immunophenotyping
Lymphocyte Activation
/ drug effects
Lymphocyte Count
Lymphoma, Follicular
/ diagnosis
Male
Middle Aged
Neoplasm Grading
Neoplasm Staging
Prednisone
Rituximab
/ administration & dosage
T-Lymphocyte Subsets
/ drug effects
Treatment Outcome
Vincristine
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
17 09 2019
17 09 2019
Historique:
received:
21
05
2019
accepted:
04
09
2019
entrez:
19
9
2019
pubmed:
19
9
2019
medline:
31
10
2020
Statut:
epublish
Résumé
Preclinical models and clinical studies have shown that anti-CD20-based treatment has multifaceted consequences on T-cell immunity. We have performed a prospective study of peripheral T-cell compartment in FL patients, all exhibiting high tumor burden and receiving rituximab-chemotherapy-based regimen (R-CHOP). Before treatment, FL patients harbor low amounts of peripheral naive T cells, but high levels of CD4
Identifiants
pubmed: 31530876
doi: 10.1038/s41598-019-50029-y
pii: 10.1038/s41598-019-50029-y
pmc: PMC6748924
doi:
Substances chimiques
Biomarkers
0
R-CHOP protocol
0
Rituximab
4F4X42SYQ6
Vincristine
5J49Q6B70F
Doxorubicin
80168379AG
Cyclophosphamide
8N3DW7272P
Prednisone
VB0R961HZT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13471Références
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