Photoswitchable Inhibitor of the Calcium Channel TRPV6.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
12 Sep 2019
12 Sep 2019
Historique:
received:
02
07
2019
accepted:
02
08
2019
entrez:
19
9
2019
pubmed:
19
9
2019
medline:
19
9
2019
Statut:
epublish
Résumé
Herein we report the first photoswitchable inhibitor of Transient Receptor Potential Vanilloid 6 (TRPV6), a selective calcium channel involved in a number of diseases and in cancer progression. By surveying analogs of a previously reported TRPV6 inhibitor appended with a phenyl-diazo group, we identified a compound switching between a weak TRPV6 inhibitor in its dark,
Identifiants
pubmed: 31531207
doi: 10.1021/acsmedchemlett.9b00298
pmc: PMC6746075
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1341-1345Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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