Super-Selective Transarterial Chemoembolization with Doxorubicin-Loaded Drug-Eluting Beads Sized Below and Above 100 Microns in Hepatocellular Carcinoma: A Comparative Study.
Chemoembolization
Doxorubicin
Drug-eluting beads
Hepatocellular carcinoma
Microspheres
Journal
Journal of the Belgian Society of Radiology
ISSN: 2514-8281
Titre abrégé: J Belg Soc Radiol
Pays: England
ID NLM: 101698198
Informations de publication
Date de publication:
29 Jul 2019
29 Jul 2019
Historique:
entrez:
19
9
2019
pubmed:
19
9
2019
medline:
19
9
2019
Statut:
epublish
Résumé
Objectives To compare efficacy and safety of super-selective DEB-TACE with doxorubicin-loaded microspheres sized below and above 100 microns for treatment of hepatocellular carcinoma (HCC). Material and methods All consecutive patients with HCC who underwent DEB-TACE were included in this retrospective study. Regarding to microsphere size (>100 microns or <100 microns), patients were determined as Group A (n = 28) and Group B (n = 30), respectively. Results Of the 58 patients (78% males), no statistically significant difference was found between the two groups in terms of age and gender (P = 0.388, P = 0.888, respectively). There were no significant differences between the two groups in terms of BCLC stages, presence of chronic liver disease, and Child-Pugh classes (P = 0.593, P = 0.081, P = 0.391, respectively). Although statistically insignificant, median overall survival (19 months vs 32 months, P = 0.190) and median progression-free survival (13 months vs 20 months (P = 0.574) were longer and 1-3-years objective response rates (7.40% vs 23.33%, P = 0.330) were higher in Group B than in Group A, respectively. No mortality or major complications were observed. Grade I/ II adverse events were detected in all patients. Transient elevations in liver function tests (Grade III adverse events) were similar in both groups (3.57% vs 3.33%; P = 0.980). Conclusion Super-selective DEB-TACE with doxorubicin-loaded microspheres sized <100 microns is an effective and safe method for the HCC treatment. Objective response rates are higher and survival durations are longer after DEB-TACE performed with doxorubicin-loaded microspheres sized below 100 microns. Keywords Chemoembolization Doxorubicin Microspheres Drug-eluting beads Hepatocellular carcinoma.
Identifiants
pubmed: 31531413
doi: 10.5334/jbsr.1841
pmc: PMC6676920
doi:
Types de publication
Journal Article
Langues
eng
Pagination
47Déclaration de conflit d'intérêts
The authors have no competing interests to declare.
Références
Hepatology. 2003 Feb;37(2):429-42
pubmed: 12540794
Gastroenterology. 2007 Jun;132(7):2557-76
pubmed: 17570226
Dig Dis Sci. 2008 May;53(5):1400-4
pubmed: 18046645
Eur Radiol. 2008 Mar;18(3):457-67
pubmed: 18058107
Cardiovasc Intervent Radiol. 2008 May-Jun;31(3):468-76
pubmed: 18228095
Cardiovasc Intervent Radiol. 2010 Feb;33(1):41-52
pubmed: 19908093
Cardiovasc Intervent Radiol. 2010 Jun;33(3):541-51
pubmed: 19937027
Cardiovasc Intervent Radiol. 2010 Jun;33(3):552-9
pubmed: 19957182
Semin Liver Dis. 2010 Feb;30(1):52-60
pubmed: 20175033
Cancer J. 2010 Mar-Apr;16(2):163-75
pubmed: 20404614
Hepatology. 2011 Mar;53(3):1020-2
pubmed: 21374666
Korean J Hepatol. 2011 Mar;17(1):51-60
pubmed: 21494078
J Hepatol. 2011 Dec;55(6):1332-8
pubmed: 21703190
J Clin Oncol. 2011 Oct 20;29(30):3960-7
pubmed: 21911714
J Vasc Interv Radiol. 2012 Feb;23(2):257-64.e4
pubmed: 22178039
Cardiovasc Intervent Radiol. 2014 Feb;37(1):165-75
pubmed: 24263774
Semin Intervent Radiol. 2013 Mar;30(1):3-11
pubmed: 24436512
Gastroenterol Hepatol (N Y). 2014 Mar;10(3):153-61
pubmed: 24829542
J Vasc Interv Radiol. 2015 Feb;26(2):262-70
pubmed: 25311967
J Vasc Interv Radiol. 2015 Apr;26(4):516-22
pubmed: 25704226
Eur Radiol. 2016 Oct;26(10):3474-82
pubmed: 26780638
World J Gastroenterol. 2016 Oct 28;22(40):8853-8861
pubmed: 27833376
World J Radiol. 2017 May 28;9(5):245-252
pubmed: 28634515
Am J Pathol. 1997 Sep;151(3):679-88
pubmed: 9284816