Significant risk of occult cancer in complex non-atypical endometrial hyperplasia.
Coexistent cancer
Complex hyperplasia
Endometrial hyperplasia
Endometrial intraepithelial neoplasia
Journal
Archives of gynecology and obstetrics
ISSN: 1432-0711
Titre abrégé: Arch Gynecol Obstet
Pays: Germany
ID NLM: 8710213
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
17
04
2019
accepted:
07
09
2019
pubmed:
19
9
2019
medline:
6
5
2020
entrez:
19
9
2019
Statut:
ppublish
Résumé
In the 2014 WHO classification of endometrial hyperplasia (EH), complex EH is lumped together with simple EH in the benign category of non-atypical EH. To assess the risk of coexistent cancer in complex EH and simple EH without atypia, through a systematic review and meta-analysis. Electronic databases were searched from their inception to January 2019 for relevant articles. Twelve studies assessing a total of 804 non-atypical EH were included. The risk of coexistent cancer was significantly higher in complex EH (12.4%) than in simple EH (2%), with an OR of 6.03 (p = 0.0002). Even in the absence of cytologic atypia, complex EH is associated with a significant risk of coexistent cancer. Further studies are necessary to investigate the need for a revision in the WHO classification.
Sections du résumé
BACKGROUND
In the 2014 WHO classification of endometrial hyperplasia (EH), complex EH is lumped together with simple EH in the benign category of non-atypical EH.
OBJECTIVE
To assess the risk of coexistent cancer in complex EH and simple EH without atypia, through a systematic review and meta-analysis.
METHODS
Electronic databases were searched from their inception to January 2019 for relevant articles.
RESULTS
Twelve studies assessing a total of 804 non-atypical EH were included. The risk of coexistent cancer was significantly higher in complex EH (12.4%) than in simple EH (2%), with an OR of 6.03 (p = 0.0002).
CONCLUSION
Even in the absence of cytologic atypia, complex EH is associated with a significant risk of coexistent cancer. Further studies are necessary to investigate the need for a revision in the WHO classification.
Identifiants
pubmed: 31531779
doi: 10.1007/s00404-019-05299-2
pii: 10.1007/s00404-019-05299-2
doi:
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM