Prognostic factors for the sequelae and severity of Guillain-Barré syndrome in children.
Adolescent
Child
Child, Preschool
Facial Paralysis
/ etiology
Female
France
Guillain-Barre Syndrome
/ complications
Hospitalization
Humans
Infant
Intubation, Intratracheal
/ statistics & numerical data
Male
Neural Conduction
Primary Dysautonomias
/ etiology
Prognosis
Recovery of Function
Retrospective Studies
Severity of Illness Index
Time Factors
Guillain-Barré syndrome
children
dysautonomia
outcome
sequelae
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
08
06
2018
revised:
05
09
2019
accepted:
06
09
2019
pubmed:
19
9
2019
medline:
14
1
2020
entrez:
19
9
2019
Statut:
ppublish
Résumé
Guillain-Barré syndrome (GBS) is an inflammatory polyradiculoneuritis. Our aim in this study was to describe the clinical characteristics and the long-term sequelae of GBS in a French pediatric population. In this multicenter, retrospective study we evaluated clinical signs, radiological examinations, laboratory tests, treatments, and outcomes. One hundred ten children were included in this investigation. These children presented with walking difficulties, muscle weakness, and cranial nerve impairment. Electrodiagnostic testing revealed 70% with acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and 16% with acute motor axonal neuropathy (AMAN). One hundred children received immunoglobulins. At follow-up, 77% were cured, whereas 9% had sequelae, associated with an axonal form (P < .01) and a short interval between symptom onset and hospitalization (P < .01). The need for intubation was correlated with peripheral facial paralysis (P < .01) and dysautonomia (P < .01). Although AIDP and AMAN present in a similar way, the axonal form is associated with a worse outcome.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
716-723Informations de copyright
© 2019 Wiley Periodicals, Inc.
Références
Afifi AK. The Landry-Guillain-Barré Strohl syndrome 1859 to 1992 a historical perspective. J Fam Commun Med. 1994;1:30-34.
Guillain G, Barré JA, Strohl A. Radiculoneuritis syndrome with hyperalbuminosis of cerebrospinal fluid without cellular reaction. Notes on clinical features and graphs of tendon reflexes. 1916 [in French]. Ann Med Interne (Paris). 1999;150:24-32.
Asbury AK. Guillain-Barré syndrome: historical aspects. Ann Neurol. 1990;27(suppl):S2-S6.
Asbury AK. New concepts of Guillain-Barré syndrome. J Child Neurol. 2000;15:183-191.
Wu X, Shen D, Li T, et al. Distinct clinical characteristics of pediatric Guillain-Barré syndrome: a comparative study between children and adults in northeast China. PLoS One. 2016;11:e0151611.
Willison HJ, Jacobs BC, van Doorn PA. Guillain-Barré syndrome. Lancet. 2016;388:717-727.
Hadden RD, Cornblath DR, Hughes RA, et al. Electrophysiological classification of Guillain-Barré syndrome: clinical associations and outcome. Ann Neurol. 1998;44:780-788.
Korinthenberg R, Schessl J, Kirschner J. Clinical presentation and course of childhood Guillain-Barré syndrome: a prospective multicentre study. Neuropediatrics. 2007;38:10-17.
Varkal MA, Uzunhan TA, Aydınlı N, Ekici B, Çalışkan M, Özmen M. Pediatric Guillain-Barré syndrome: indicators for a severe course. Ann Indian Acad Neurol. 2015;18:24-28.
Lee JH, Sung IY, Rew IS. Clinical presentation and prognosis of childhood Guillain-Barré syndrome. J Paediatr Child Health. 2008;44:449-454.
Tang J, Dai Y, Li M, et al. Guillain-Barré syndrome in Chinese children: a retrospective analysis. Pediatr Neurol. 2011;45:233-237.
Salehiomran MR, Nikkhah A, Mahdavi M. Prognosis of Guillain-Barré syndrome in Children. Iran J Child Neurol. 2016;10:38-41.
Akbayram S, Doğan M, Akgün C, et al. Clinical features and prognosis with Guillain-Barré syndrome. Ann Indian Acad Neurol. 2011;14:98-102.
Walgaard C, Lingsma HF, Ruts L, et al. Prediction of respiratory insufficiency in Guillain-Barré syndrome. Ann Neurol. 2010;67:781-787.
Schessl J, Koga M, Funakoshi K, et al. Prospective study on anti-ganglioside antibodies in childhood Guillain-Barré syndrome. Arch Dis Child. 2007;92:48-52.
Willison HJ, Yuki N. Peripheral neuropathies and anti-glycolipid antibodies. Brain J Neurol. 2002;125:2591-2625.
Ogawara K, Kuwabara S, Mori M, Hattori T, Koga M, Yuki N. Axonal Guillain-Barré syndrome: relation to anti-ganglioside antibodies and Campylobacter jejuni infection in Japan. Ann Neurol. 2000;48:624-631.
Paradiso G, Tripoli J, Galicchio S, Fejerman N. Epidemiological, clinical, and electrodiagnostic findings in childhood Guillain-Barré syndrome: a reappraisal. Ann Neurol. 1999;46:701-717.
Chareyre J, Hully M, Simonnet H, et al. Acute axonal neuropathy subtype of Guillain Barré syndrome in a French pediatric series: adequate follow-up may require repetitive electrophysiological studies. Eur J Paediatr Neurol. 2017;21:891-897.
Tekgul H, Serdaroglu G, Tutuncuoglu S. Outcome of axonal and demyelinating forms of Guillain-Barré syndrome in children. Pediatr Neurol. 2003;28:295-299.
Nagasawa K, Kuwabara S, Misawa S, et al. Electrophysiological subtypes and prognosis of childhood Guillain-Barré syndrome in Japan. Muscle Nerve. 2006;33:766-770.
Kokubun N, Nishibayashi M, Uncini A, Odaka M, Hirata K, Yuki N. Conduction block in acute motor axonal neuropathy. Brain J Neurol. 2010;133:2897-2908.
Roodbol J, de Wit M-CY, Aarsen FK, Catsman-Berrevoets CE, Jacobs BC. Long-term outcome of Guillain-Barré syndrome in children. J Peripher Nerv Syst. 2014;19:121-126.