Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia.

Animals Cardiotonic Agents / metabolism Carrier Proteins / genetics Female Gene Expression Regulation Heart / physiopathology Humans Lipid Metabolism Liver / metabolism Male Mice, Knockout Middle Aged Myocardial Infarction / diagnostic imaging Myocardial Ischemia / genetics Polymorphism, Single Nucleotide / genetics Protein Isoforms / genetics RNA, Messenger / genetics
Expression Function Heart MTTP Polymorphism

Journal

Journal of molecular and cellular cardiology
ISSN: 1095-8584
Titre abrégé: J Mol Cell Cardiol
Pays: England
ID NLM: 0262322

Informations de publication

Date de publication:
12 2019
Historique:
received: 24 08 2019
accepted: 06 09 2019
pubmed: 19 9 2019
medline: 10 7 2020
entrez: 19 9 2019
Statut: ppublish

Résumé

The microsomal triglyceride transport protein (MTTP) is critical for assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins and is most abundant in the liver and intestine. Surprisingly, MTTP is also expressed in the heart. Here we tested the functional relevance of cardiac MTTP expression. We combined clinical studies, advanced expression analysis of human heart biopsies and analyses in genetically modified mice lacking cardiac expression of the MTTP-A isoform of MTTP. Our results indicate that lower cardiac MTTP expression in humans is associated with structural and perfusion abnormalities in patients with ischemic heart disease. MTTP-A deficiency in mice heart does not affect total MTTP expression, activity or lipid concentration in the heart. Despite this, MTTP-A deficient mice displayed impaired cardiac function after a myocardial infarction. Expression analysis of MTTP indicates that MTTP expression is linked to cardiac function and responses in the heart. Our results indicate that MTTP may play an important role for the heart function in conjunction to ischemic events.

Identifiants

DOI: 10.1016/j.yjmcc.2019.09.003 PMID: 31533023
pubmed: 31533023
pii: S0022-2828(19)30186-5
doi: 10.1016/j.yjmcc.2019.09.003
pii:
doi:

Substances chimiques

Cardiotonic Agents 0
Carrier Proteins 0
Protein Isoforms 0
RNA, Messenger 0
microsomal triglyceride transfer protein 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-8

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Martina Klevstig (M)

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.

Muhammad Arif (M)

Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.

Maria Mannila (M)

Cardiovascular Medicine Unit, Department of Medicine, Center for Molecular Medicine at BioClinicum, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

Sara Svedlund (S)

Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden.

Ismena Mardani (I)

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.

Marcus Ståhlman (M)

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.

Linda Andersson (L)

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.

Malin Lindbom (M)

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.

Azra Miljanovic (A)

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.

Anders Franco-Cereceda (A)

Department of Cardiothoracic Surgery and Anaesthesia, Karolinska University Hospital, Stockholm, Sweden.

Per Eriksson (P)

Cardiovascular Medicine Unit, Department of Medicine, Center for Molecular Medicine at BioClinicum, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

Anders Jeppsson (A)

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.

Li-Ming Gan (LM)

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden; Cardiovascular, Renal and Metabolism IMED Biotech Unit, AstraZeneca R&D, Gothenburg, Mölndal, Sweden.

Malin Levin (M)

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.

Adil Mardinoglu (A)

Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.

Ewa Ehrenborg (E)

Cardiovascular Medicine Unit, Department of Medicine, Center for Molecular Medicine at BioClinicum, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden. Electronic address: Ewa.Ehrenborg@ki.se.

Jan Borén (J)

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address: jan.boren@wlab.gu.se.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cardiac expression of the microsomal...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Cardiotoniques › Cardiac expression of the microsomal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Cardiac expression of the microsomal...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Cardiac expression of the microsomal...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Cardiac expression of the microsomal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cardiac expression of the microsomal...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Cardiac expression of the microsomal...
questionsmedicales.fr › Système digestif › Foie › Cardiac expression of the microsomal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Cardiac expression of the microsomal...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Cardiac expression of the microsomal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Cardiac expression of the microsomal...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Cardiac expression of the microsomal...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Cardiac expression of the microsomal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Cardiac expression of the microsomal...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Cardiac expression of the microsomal...