Spinal Reactive Oxygen Species and Oxidative Damage Mediate Chronic Pain in Lame Dairy Cows.
bovine
chronic pain
lameness
oxidative stress
Journal
Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614
Informations de publication
Date de publication:
17 Sep 2019
17 Sep 2019
Historique:
received:
17
08
2019
revised:
11
09
2019
accepted:
14
09
2019
entrez:
20
9
2019
pubmed:
20
9
2019
medline:
20
9
2019
Statut:
epublish
Résumé
Lameness in dairy cows is a worldwide prevalent disease with a negative impact on animal welfare and herd economy. Oxidative damage and antioxidant system dysfunction are common features of many CNS diseases, including chronic pain. The aim of this study was to evaluate the levels of reactive oxygen species (ROS) and oxidative damage markers in the spinal cord of dairy cows with chronic inflammatory lameness. Locomotion score was performed in order to select cows with chronic lameness. Dorsal horn spinal cord samples were obtained post mortem from lumbar segments (L2-L5), and ROS, malondialdehyde (MDA), and carbonyl groups were measured along with the activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and total antioxidant response (TAR). Lame cows had increased levels of ROS, MDA, and carbonyl groups, while no differences were observed between lame and non-lame cows in SOD, GPx, CAT, and TAR activity. We conclude that painful chronic inflammatory lameness in dairy cows is associated with an increase in ROS, MDA, and carbonyl groups. Nonetheless, an association between ROS generation and dysfunction of the antioxidant system, as previously proposed, could not be established.
Identifiants
pubmed: 31533257
pii: ani9090693
doi: 10.3390/ani9090693
pmc: PMC6770087
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Comisión Nacional de Investigación Científica y Tecnológica
ID : 21150613
Références
Antioxid Redox Signal. 2014 Jul 20;21(3):396-413
pubmed: 24702237
J Clin Biochem Nutr. 2008 Nov;43(3):131-8
pubmed: 19015746
Pain. 2011 Apr;152(4):844-52
pubmed: 21296500
J Pain. 2009 Sep;10(9):895-926
pubmed: 19712899
Redox Rep. 2006;11(3):131-5
pubmed: 16805968
Trends Endocrinol Metab. 2012 Aug;23(8):399-406
pubmed: 22742812
Arthritis Rheumatol. 2015 Mar;67(3):645-55
pubmed: 25417811
J Proteomics. 2019 Jan 6;190:1-11
pubmed: 29653266
Swiss Med Wkly. 2012 Aug 17;142:w13659
pubmed: 22903797
J Pain Res. 2017 Mar 20;10:653-662
pubmed: 28360534
Anal Biochem. 2018 Feb 1;542:29-33
pubmed: 29175424
J Dairy Sci. 2006 Jul;89(7):2519-28
pubmed: 16772570
Life Sci. 2016 Apr 1;150:50-60
pubmed: 26921631
J Lab Clin Med. 1967 Jul;70(1):158-69
pubmed: 6066618
Clin Biochem. 2004 Feb;37(2):112-9
pubmed: 14725941
Biol Trace Elem Res. 2015 Mar;164(1):43-9
pubmed: 25534290
Br J Pharmacol. 2015 Jan;172(2):324-33
pubmed: 24640991
Neuroscience. 1999;94(2):595-605
pubmed: 10579220
Sci Rep. 2015 Jun 25;5:11555
pubmed: 26109318
J Dairy Sci. 2011 Oct;94(10):5045-52
pubmed: 21943755
Br J Pharmacol. 2002 Jan;135(2):520-36
pubmed: 11815388
Physiol Genomics. 2007 Apr 24;29(2):215-30
pubmed: 17213366
Biotechnol Bioeng. 2011 Dec;108(12):2777-93
pubmed: 21809331
Acta Biochim Pol. 2010;57(3):313-9
pubmed: 20827448
Trends Neurosci. 2016 Dec;39(12):862-879
pubmed: 27842920
BMC Vet Res. 2015 Apr 30;11:101
pubmed: 25926287
Anal Biochem. 2014 Aug 1;458:69-71
pubmed: 24814294
Pain. 2007 Dec 15;133(1-3):9-17
pubmed: 17379413
Curr Top Med Chem. 2015;15(5):446-57
pubmed: 25620241
Eur J Pharmacol. 2011 Jan 10;650(1):184-94
pubmed: 20868662
Neurochem Res. 2019 Apr;44(4):763-775
pubmed: 30603983
J Cell Mol Med. 2006 Apr-Jun;10(2):389-406
pubmed: 16796807
Anal Biochem. 1979 Jun;95(2):351-8
pubmed: 36810
Mol Pain. 2008 Aug 12;4:33
pubmed: 18700027
Brain Res Bull. 2009 Dec 16;80(6):422-7
pubmed: 19683561
J Headache Pain. 2016;17:10
pubmed: 26883365
Pain. 2007 Oct;131(3):262-71
pubmed: 17317010
J Vet Intern Med. 2016 Jul;30(4):1138-48
pubmed: 27334504
Res Vet Sci. 2012 Feb;92(1):138-41
pubmed: 21074230
Aging Dis. 2018 Feb 1;9(1):143-150
pubmed: 29392089
Int J Mol Sci. 2016 Mar 02;17(3):327
pubmed: 26950115
J Neurochem. 2014 Nov;131(4):413-7
pubmed: 25051888
Animals (Basel). 2018 Jul 20;8(7):null
pubmed: 30037055
Exp Neurobiol. 2014 Dec;23(4):372-80
pubmed: 25548537
J Neurosci Res. 2010 Nov 15;88(15):3376-85
pubmed: 20857508
Neuroscience. 2013 Sep 5;247:201-12
pubmed: 23707800
Pain. 2015 Apr;156 Suppl 1:S11-7
pubmed: 25789427
Neurosci Lett. 2005 Jun 24;381(3):289-93
pubmed: 15896486
Trends Mol Med. 2003 Apr;9(4):169-76
pubmed: 12727143
Animals (Basel). 2017 Nov 05;7(11):null
pubmed: 29113033
Front Mol Neurosci. 2019 Feb 22;12:42
pubmed: 30853891
Free Radic Biol Med. 2011 Sep 1;51(5):951-66
pubmed: 21277369
Neurosci Lett. 2006 Jan 2;391(3):108-11
pubmed: 16183198
Pain. 2017 Sep;158(9):1633-1646
pubmed: 28614187
Curr Med Chem. 2007;14(4):417-30
pubmed: 17305543
J Am Chem Soc. 2011 May 11;133(18):7016-24
pubmed: 21506564
Osteoarthritis Cartilage. 2018 Feb;26(2):175-183
pubmed: 29180098
Brain Res. 2005 Jul 19;1050(1-2):72-8
pubmed: 15979588
J Vet Sci. 2015;16(4):405-11
pubmed: 26243595
Mass Spectrom Rev. 2014 Mar-Apr;33(2):79-97
pubmed: 23832618
J Dairy Sci. 2002 Sep;85(9):2250-6
pubmed: 12362457
Oxid Med Cell Longev. 2014;2014:360438
pubmed: 24999379
Adv Neurobiol. 2017;16:225-253
pubmed: 28828613
J Dairy Sci. 2016 Jul;99(7):5640-5648
pubmed: 27132100
Free Radic Biol Med. 2007 Oct 1;43(7):995-1022
pubmed: 17761297
Br J Pharmacol. 2003 Oct;140(3):445-60
pubmed: 14522841
Circ Res. 2011 Jan 21;108(2):235-48
pubmed: 21252151
Neuropharmacology. 2017 Feb;113(Pt A):137-147
pubmed: 27712995
J Pharmacol Exp Ther. 2004 Jun;309(3):869-78
pubmed: 14988418
Neuroscience. 1998 Feb;82(3):915-25
pubmed: 9483545