HIF-1α is a key mediator of the lung inflammatory potential of lithium-ion battery particles.
Animals
Bronchoalveolar Lavage Fluid
/ chemistry
Cell Culture Techniques
Cell Line
Cobalt
/ toxicity
Cytokines
/ analysis
Dose-Response Relationship, Drug
Epithelial Cells
/ drug effects
Female
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
/ metabolism
Inhalation Exposure
Ions
Lung
/ drug effects
Mice
Mice, Inbred C57BL
Oxides
/ toxicity
Particle Size
Pneumonia
/ chemically induced
Biomarker
Cobalt
IL-1β, Epithelial cells
Nickel
Predictive toxicology
Journal
Particle and fibre toxicology
ISSN: 1743-8977
Titre abrégé: Part Fibre Toxicol
Pays: England
ID NLM: 101236354
Informations de publication
Date de publication:
18 09 2019
18 09 2019
Historique:
received:
31
05
2019
accepted:
29
08
2019
entrez:
20
9
2019
pubmed:
20
9
2019
medline:
25
2
2020
Statut:
epublish
Résumé
Li-ion batteries (LIB) are increasingly used worldwide. They are made of low solubility micrometric particles, implying a potential for inhalation toxicity in occupational settings and possibly for consumers. LiCoO By testing a set of 5 selected LIB particles (LCO, LiNiMnCoO We conclude that HIF-1α, stabilized in lung cells by released Co and Ni ions, is a mechanism-based biomarker of lung inflammatory responses induced by LIB particles containing Co/Ni. Documenting the Co/Ni content of LIB particles, their bioaccessibility and their capacity to stabilize HIF-1α in vitro can be used to predict the lung inflammatory potential of LIB particles.
Sections du résumé
BACKGROUND
Li-ion batteries (LIB) are increasingly used worldwide. They are made of low solubility micrometric particles, implying a potential for inhalation toxicity in occupational settings and possibly for consumers. LiCoO
RESULTS
By testing a set of 5 selected LIB particles (LCO, LiNiMnCoO
CONCLUSIONS
We conclude that HIF-1α, stabilized in lung cells by released Co and Ni ions, is a mechanism-based biomarker of lung inflammatory responses induced by LIB particles containing Co/Ni. Documenting the Co/Ni content of LIB particles, their bioaccessibility and their capacity to stabilize HIF-1α in vitro can be used to predict the lung inflammatory potential of LIB particles.
Identifiants
pubmed: 31533843
doi: 10.1186/s12989-019-0319-z
pii: 10.1186/s12989-019-0319-z
pmc: PMC6751682
doi:
Substances chimiques
Cytokines
0
Hif1a protein, mouse
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Ions
0
Oxides
0
lithium cobalt oxide
0
Cobalt
3G0H8C9362
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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