Atlastin Endoplasmic Reticulum-Shaping Proteins Facilitate Zika Virus Replication.
Antiviral Agents
/ pharmacology
Cytopathogenic Effect, Viral
Endoplasmic Reticulum
/ metabolism
GTP Phosphohydrolases
/ genetics
GTP-Binding Proteins
Gene Knockout Techniques
HeLa Cells
Humans
Membrane Proteins
Viral Nonstructural Proteins
/ genetics
Virus Release
Virus Replication
/ physiology
Zika Virus
/ drug effects
Zika Virus Infection
/ metabolism
Zika
atlastin
endoplasmic reticulum
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
01 12 2019
01 12 2019
Historique:
received:
21
06
2019
accepted:
08
09
2019
pubmed:
20
9
2019
medline:
17
6
2020
entrez:
20
9
2019
Statut:
epublish
Résumé
The endoplasmic reticulum (ER) is the site for Zika virus (ZIKV) replication and is central to the cytopathic effects observed in infected cells. ZIKV induces the formation of ER-derived large cytoplasmic vacuoles followed by "implosive" cell death. Little is known about the nature of the ER factors that regulate flavivirus replication. Atlastins (ATL1, -2, and -3) are dynamin-related GTPases that control the structure and the dynamics of the ER membrane. We show here that ZIKV replication is significantly decreased in the absence of ATL proteins. The appearance of infected cells is delayed, the levels of intracellular viral proteins and released virus are reduced, and the cytopathic effects are strongly impaired. We further show that ATL3 is recruited to viral replication sites and interacts with the nonstructural viral proteins NS2A and NS2B3. Thus, proteins that shape and maintain the ER tubular network ensure efficient ZIKV replication.
Identifiants
pubmed: 31534046
pii: JVI.01047-19
doi: 10.1128/JVI.01047-19
pmc: PMC6854498
pii:
doi:
Substances chimiques
Antiviral Agents
0
Membrane Proteins
0
Viral Nonstructural Proteins
0
ATL1 protein, human
EC 3.6.1.-
ATL2 protein, human
EC 3.6.1.-
GTP Phosphohydrolases
EC 3.6.1.-
GTP-Binding Proteins
EC 3.6.1.-
ATL3 protein, human
EC 3.6.5.-
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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