Prognostic and diagnostic role of PSA immunohistochemistry: A tissue microarray study on 21,000 normal and cancerous tissues.
immunohistochemistry
prognosis marker
prostate specific antigen
specificity
tissue microarray
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
10 Sep 2019
10 Sep 2019
Historique:
received:
07
05
2019
accepted:
17
07
2019
entrez:
20
9
2019
pubmed:
20
9
2019
medline:
20
9
2019
Statut:
epublish
Résumé
To assess the prognostic and diagnostic utility of PSA immunostaining, tissue microarrays containing 17,747 prostate cancers, 3,442 other tumors from 82 different (sub) types and 608 normal tissues were analyzed at two different antibody concentrations (1:100 and 1:800). In normal tissues, PSA expression was limited to prostate epithelial cells. In prostate cancers, PSA staining was seen in 99.9-100% (1:800-1:100) primary tumors, 98.7-99.7% of advanced recurrent cancers, in 84.6-91.4% castration resistant cancers, and in 7.7-18.8% of 16 small cell carcinomas. Among extraprostatic tumors, PSA stained positive in 0-3 (1:800-1:100) of 19 osteosarcomas, 1-2 of 34 ovarian cancers, 0-2 of 35 malignant mesotheliomas, 0-1 of 21 thyroid gland carcinomas and 0-1 of 26 large cell lung cancers. Reduced staining intensity and loss of apical staining were strongly linked to unfavorable tumor phenotype and poor prognosis (
Identifiants
pubmed: 31534629
doi: 10.18632/oncotarget.27145
pii: 27145
pmc: PMC6739211
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5439-5453Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST G. Sauter and R. Simon have developed the anti-PSA antibody (DIA-PSA, clone HAM18) in cooperation with Dianova GmbH, Warburgstraße 45, 20354 Hamburg.
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