Impact of Sequence Specificity of Spherical Nucleic Acids on Macrophage Activation in Vitro and in Vivo.
G-quadruplex
gold nanoparticles
macrophage activation
spherical nucleic acids
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
07 10 2019
07 10 2019
Historique:
pubmed:
20
9
2019
medline:
18
6
2020
entrez:
20
9
2019
Statut:
ppublish
Résumé
The effects of spherical nucleic acid (SNA) gold nanoparticle conjugates on the activation of macrophages in vitro and release of cytokines in vivo were explored. Herein, we show that G-quadruplexes, the formation of which is enhanced on gold nanoparticle surfaces, elicit an increase in cytokine release from mouse and human macrophages and induce the upregulation of activation receptors as well as NO
Identifiants
pubmed: 31536368
doi: 10.1021/acs.molpharmaceut.9b00561
pmc: PMC6894393
mid: NIHMS1059886
doi:
Substances chimiques
Cytokines
0
Nucleic Acids
0
Gold
7440-57-5
Nitrogen Dioxide
S7G510RUBH
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4223-4229Subventions
Organisme : NIGMS NIH HHS
ID : F31 GM119392
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM079300
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM105538
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA199091
Pays : United States
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