Commensal E. coli rapidly transfer antibiotic resistance genes to human intestinal microbiota in the Mucosal Simulator of the Human Intestinal Microbial Ecosystem (M-SHIME).


Journal

International journal of food microbiology
ISSN: 1879-3460
Titre abrégé: Int J Food Microbiol
Pays: Netherlands
ID NLM: 8412849

Informations de publication

Date de publication:
02 Dec 2019
Historique:
received: 12 12 2018
revised: 28 08 2019
accepted: 06 09 2019
pubmed: 20 9 2019
medline: 2 1 2020
entrez: 20 9 2019
Statut: ppublish

Résumé

Food-producing animals are indicated as a reservoir of antibiotic resistance genes and a potential vector for transmission of plasmid-encoded antibiotic resistance genes by conjugation to the human intestinal microbiota. In this study, transfer of an antibiotic resistance plasmid from a commensal E. coli originating from a broiler chicken towards the human intestinal microbiota was assessed by using a Mucosal Simulator of the Human Intestinal Microbial Ecosystem (M-SHIME). This in vitro model mimics the human intestinal ecosystem and received a single dose of 10

Identifiants

pubmed: 31536878
pii: S0168-1605(19)30287-9
doi: 10.1016/j.ijfoodmicro.2019.108357
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Cefotaxime N2GI8B1GK7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

108357

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Ellen Lambrecht (E)

CMET, Center for Microbial Ecology and Technology, Ghent University, Coupure links 653, 9000 Gent, Belgium; ILVO, Flanders Research Institute for Agriculture, Fisheries and Food, Brusselsesteenweg 370, 9090 Melle, Belgium. Electronic address: ellen.lambrecht@ugent.be.

Els Van Coillie (E)

ILVO, Flanders Research Institute for Agriculture, Fisheries and Food, Brusselsesteenweg 370, 9090 Melle, Belgium. Electronic address: els.vancoillie@ilvo.vlaanderen.be.

Eva Van Meervenne (E)

CMET, Center for Microbial Ecology and Technology, Ghent University, Coupure links 653, 9000 Gent, Belgium; ILVO, Flanders Research Institute for Agriculture, Fisheries and Food, Brusselsesteenweg 370, 9090 Melle, Belgium.

Nico Boon (N)

CMET, Center for Microbial Ecology and Technology, Ghent University, Coupure links 653, 9000 Gent, Belgium. Electronic address: nico.boon@ugent.be.

Marc Heyndrickx (M)

ILVO, Flanders Research Institute for Agriculture, Fisheries and Food, Brusselsesteenweg 370, 9090 Melle, Belgium; Department of Pathology, Bacteriology and Avian Diseases, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. Electronic address: marc.heyndrickx@ilvo.vlaanderen.be.

Tom Van de Wiele (T)

CMET, Center for Microbial Ecology and Technology, Ghent University, Coupure links 653, 9000 Gent, Belgium. Electronic address: tom.vandewiele@ugent.be.

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Classifications MeSH