Serum CD95L Level Correlates with Tumor Immune Infiltration and Is a Positive Prognostic Marker for Advanced High-Grade Serous Ovarian Cancer.
Apoptosis
/ genetics
B-Lymphocytes
/ immunology
Biomarkers, Tumor
/ blood
Cell Movement
/ genetics
Cell Proliferation
/ genetics
Cystadenocarcinoma, Serous
/ blood
Fas Ligand Protein
/ blood
Female
Forkhead Transcription Factors
/ genetics
Humans
Lymphocytes, Tumor-Infiltrating
/ immunology
Middle Aged
Neoplasm Staging
Ovarian Neoplasms
/ blood
Prognosis
T-Lymphocytes, Regulatory
/ immunology
Journal
Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
26
04
2019
revised:
15
07
2019
accepted:
10
09
2019
pubmed:
21
9
2019
medline:
23
6
2020
entrez:
21
9
2019
Statut:
ppublish
Résumé
Soluble CD95L (s-CD95L) is a chemoattractant for certain lymphocyte subpopulations. We examined whether this ligand is a prognostic marker for high-grade serous ovarian cancer (HGSOC) and whether it is associated with accumulation of immune cells in the tumor. Serum s-CD95L levels in 51 patients with advanced ovarian cancer were tested by ELISA. IHC staining of CD3, CD4, CD8, CD20, CD163, CD31, FoxP3, CCR6, IL-17, Granzyme B, PD-L1, and membrane CD95L was used to assess tumor-infiltrating immune cells. Although the intensity of CD3, CD8, CD4, CD20, and CD163 in tumor tissues remained constant regardless of membrane CD95L expression, tumors in patients with HGSOC with s-CD95L levels ≥516 pg/mL showed increased infiltration by CD3
Identifiants
pubmed: 31537619
pii: 1541-7786.MCR-19-0449
doi: 10.1158/1541-7786.MCR-19-0449
doi:
Substances chimiques
Biomarkers, Tumor
0
FOXP3 protein, human
0
Fas Ligand Protein
0
Forkhead Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2537-2548Informations de copyright
©2019 American Association for Cancer Research.