Bidirectional transport of 2-chloroadenosine by equilibrative nucleoside transporter 4 (hENT4): Evidence for allosteric kinetics at acidic pH.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
19 09 2019
19 09 2019
Historique:
received:
28
02
2019
accepted:
02
09
2019
entrez:
21
9
2019
pubmed:
21
9
2019
medline:
27
10
2020
Statut:
epublish
Résumé
Adenosine has been reported to be transported by equilibrative nucleoside transporter 4 (ENT4), encoded by the SLC29A4 gene, in an acidic pH-dependent manner. This makes hENT4 of interest as a therapeutic target in acidic pathologies where adenosine is protective (e.g. vascular ischaemia). We examined the pH-sensitivity of nucleoside influx and efflux by hENT4 using a recombinant transfection model that lacks the confounding influences of other nucleoside transporters (PK15-NTD). We established that [
Identifiants
pubmed: 31537831
doi: 10.1038/s41598-019-49929-w
pii: 10.1038/s41598-019-49929-w
pmc: PMC6753126
doi:
Substances chimiques
Equilibrative Nucleoside Transport Proteins
0
SLC29A4 protein, human
0
Tritium
10028-17-8
2-Chloroadenosine
146-77-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13555Références
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