Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes.
CAR
Environmental health
Environmental science
Liver microsomes
Nuclear receptor activation
PPARα
PXR
Pesticide
Pyrethroid pesticide
Toxicology
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
21
06
2019
revised:
23
08
2019
accepted:
09
09
2019
entrez:
21
9
2019
pubmed:
21
9
2019
medline:
21
9
2019
Statut:
epublish
Résumé
In this study, we used reporter gene assays in COS-1 cells to examine the activation of rat pregnane X receptor (PXR), rat constitutive androstane receptor (CAR) and rat peroxisome-proliferator activated receptor (PPAR)α by pyrethroid pesticides, and to understand the effects of metabolic modification on their activities. All eight pyrethroids tested in this study showed rat PXR agonistic activity; deltamethrin was the most potent, followed by
Identifiants
pubmed: 31538121
doi: 10.1016/j.heliyon.2019.e02466
pii: S2405-8440(19)36126-2
pii: e02466
pmc: PMC6745485
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e02466Références
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