Sporotrichosis in the Highlands of Madagascar, 2013-2017
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Antifungal Agents
/ therapeutic use
Child
Child, Preschool
Cross-Sectional Studies
Female
Humans
Itraconazole
/ therapeutic use
Madagascar
/ epidemiology
Male
Middle Aged
Polymerase Chain Reaction
Prevalence
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Sporothrix
Sporotrichosis
/ drug therapy
Young Adult
Madagascar
Sporothrix schenckii
Sporotrichosis
clinical presentation
epidemiology
fungi
highlands
molecular diagnosis
outcome
prevalence
zoonoses
Journal
Emerging infectious diseases
ISSN: 1080-6059
Titre abrégé: Emerg Infect Dis
Pays: United States
ID NLM: 9508155
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
entrez:
21
9
2019
pubmed:
21
9
2019
medline:
15
7
2020
Statut:
ppublish
Résumé
Sporotrichosis is a saprozoonotic fungal infection found mostly in tropical and subtropical areas. Few case reports in Madagascar have been published. To document sporotrichosis epidemiology in Madagascar, we conducted a cross-sectional study. During March 2013-June 2017, we recruited from select hospitals in Madagascar patients with chronic cutaneous lesions suggestive of dermatomycosis. Sporotrichosis was diagnosed for 63 (42.5%) of 148 patients. All but 1 patient came from the central highlands, where the prevalence was 0.21 cases/100,000 inhabitants. Frequency was high (64.7%) among patients <18 years of age. Sporotrichosis was diagnosed for 73.8% of patients with arm lesions, 32.3% with leg lesions, and 15.4% with lesions at other sites. Molecular identification identified 53 Sporothrix schenckii isolates. Among the 32 patients who were followed up, response to itraconazole was complete or major for 15 and minor for 17. Overall, endemicity of sporotrichosis in Madagascar was high, concentrated in the highlands.
Identifiants
pubmed: 31538565
doi: 10.3201/eid2510.190700
pmc: PMC6759251
doi:
Substances chimiques
Antifungal Agents
0
Itraconazole
304NUG5GF4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1893-1902Références
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