Design and Development of Photonic Biosensors for Swine Viral Diseases Detection.
antibody
photonic integrated circuit (PIC)
photonics
ring resonator
swine disease
Journal
Sensors (Basel, Switzerland)
ISSN: 1424-8220
Titre abrégé: Sensors (Basel)
Pays: Switzerland
ID NLM: 101204366
Informations de publication
Date de publication:
15 Sep 2019
15 Sep 2019
Historique:
received:
24
08
2019
revised:
11
09
2019
accepted:
12
09
2019
entrez:
22
9
2019
pubmed:
22
9
2019
medline:
7
2
2020
Statut:
epublish
Résumé
In this paper we introduce a field diagnostic device based on the combination of advanced bio-sensing and photonics technologies, to tackle emerging and endemic viruses causing swine epidemics, and consequently significant economic damage in farms. The device is based on the use of microring resonators fabricated in silicon nitride with CMOS compatible techniques. In the paper, the designed and fabricated photonic integrated circuit (PIC) sensors are presented and characterized, showing an optimized performance in terms of optical losses (30 dB per ring) and extinction ration for ring resonances (15 dB). Furthermore, the results of an experiment for porcine circovirus 2 (PCV2) detection by using the developed biosensors are presented. Positive detection for different virus concentrations has been obtained. The device is currently under development in the framework of the EU Commission co-funded project SWINOSTICS.
Identifiants
pubmed: 31540156
pii: s19183985
doi: 10.3390/s19183985
pmc: PMC6766991
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Horizon 2020
ID : 771649- SWINOSTICS project
Références
Arch Virol. 2016 Mar;161(3):755-68
pubmed: 26608064
Sensors (Basel). 2015 Aug 26;15(9):20990-1015
pubmed: 26343653
Sensors (Basel). 2012;12(8):10713-41
pubmed: 23112625
Opt Express. 2007 May 28;15(11):6846-56
pubmed: 19546997
Sensors (Basel). 2019 Jan 20;19(2):null
pubmed: 30669504
Lab Chip. 2010 Feb 7;10(3):281-90
pubmed: 20090999
Biosens Bioelectron. 2016 Jun 15;80:682-690
pubmed: 26826877
Transbound Emerg Dis. 2017 Dec;64(6):1945-1952
pubmed: 27882679
Virology. 1993 Mar;193(1):503-6
pubmed: 8438586
Vet Res. 2016 Dec 3;47(1):121
pubmed: 27912792