New Poly(Propylene Imine) Dendrimer Modified with Acridine and Its Cu(II) Complex: Synthesis, Characterization and Antimicrobial Activity.
acridine
antibacterial cotton
antimicrobial activity
dendrimer
metallodendrimer
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
18 Sep 2019
18 Sep 2019
Historique:
received:
21
07
2019
revised:
12
09
2019
accepted:
16
09
2019
entrez:
22
9
2019
pubmed:
22
9
2019
medline:
22
9
2019
Statut:
epublish
Résumé
A second-generation poly(propylene imine) dendrimer modified with acridine and its Cu(II) complex have been synthesized for the first time. It has been found that two copper ions form complexes with the nitrogen atoms of the dendrimeric core by coordinate bonds. The new compounds have been characterized by nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR), fourier-transform infrared spectroscopy (FTIR) and fluorescence spectroscopy. The spectral characteristics of the modified dendrimer have been measured in different organic solvents, and a negative fluorescence solvatochromism has been observed. The antimicrobial activity of the dendrimers has been tested against model pathogenic microorganisms in agar and by broth dilution method. The cotton fabric treated with both dendrimers has been evaluated towards pathogenic microorganisms. The obtained modified cotton fabrics have been shown to hamper bacterial growth and to prevent biofilm formation. Dendrimer cytotoxicity has been investigated in vitro in the model HEp-2 cell line.
Identifiants
pubmed: 31540365
pii: ma12183020
doi: 10.3390/ma12183020
pmc: PMC6766332
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fund "Scientific Research", Ministry of Education and Science of Bulgaria
ID : КОСТ 01/24-2017
Organisme : Ministry of Economy and Competitively of Spain
ID : RTI2018-096328-B-I00
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