Ancestral roles of the Fam20C family of secreted protein kinases revealed in


Journal

The Journal of cell biology
ISSN: 1540-8140
Titre abrégé: J Cell Biol
Pays: United States
ID NLM: 0375356

Informations de publication

Date de publication:
04 11 2019
Historique:
received: 06 07 2018
revised: 11 07 2019
accepted: 25 08 2019
pubmed: 22 9 2019
medline: 14 5 2020
entrez: 22 9 2019
Statut: ppublish

Résumé

Fam20C is a secreted protein kinase mutated in Raine syndrome, a human skeletal disorder. In vertebrates, bone and enamel proteins are major Fam20C substrates. However, Fam20 kinases are conserved in invertebrates lacking bone and enamel, suggesting other ancestral functions. We show that FAMK-1, the

Identifiants

pubmed: 31541016
pii: jcb.201807041
doi: 10.1083/jcb.201807041
pmc: PMC6829671
doi:

Substances chimiques

Casein Kinase I EC 2.7.11.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3795-3811

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM074215
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM110268
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK018849
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK018024
Pays : United States
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States

Informations de copyright

© 2019 Gerson-Gurwitz et al.

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Auteurs

Adina Gerson-Gurwitz (A)

Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA.
Department of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA.

Carolyn A Worby (CA)

Department of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA.
Department of Pharmacology, University of California, San Diego, La Jolla, CA.

Kian-Yong Lee (KY)

Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA.
Department of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA.

Renat Khaliullin (R)

Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA.
Department of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA.

Jeff Bouffard (J)

Department of Bioengineering, Northeastern University, Boston, MA.

Dhanya Cheerambathur (D)

Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA.
Department of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA.

Karen Oegema (K)

Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA.
Department of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA.

Erin J Cram (EJ)

Department of Biology, Northeastern University, Boston, MA.

Jack E Dixon (JE)

Department of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA jedixon@ucsd.edu.
Department of Pharmacology, University of California, San Diego, La Jolla, CA.

Arshad Desai (A)

Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA abdesai@ucsd.edu.
Department of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA.

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Classifications MeSH