Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross.
Animals
Anopheles
/ parasitology
Antimalarials
/ pharmacology
Chloroquine
/ pharmacology
Crosses, Genetic
Culicidae
/ parasitology
Drug Discovery
Drug Resistance
/ genetics
Female
Gene Expression
Genes, Protozoan
Malaria
/ drug therapy
Malaria, Vivax
/ drug therapy
Male
Membrane Transport Proteins
/ genetics
Plasmodium falciparum
/ genetics
Plasmodium vivax
/ drug effects
Protozoan Proteins
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
20 09 2019
20 09 2019
Historique:
received:
15
02
2019
accepted:
26
08
2019
entrez:
22
9
2019
pubmed:
22
9
2019
medline:
7
1
2020
Statut:
epublish
Résumé
Mainstay treatment for Plasmodium vivax malaria has long relied on chloroquine (CQ) against blood-stage parasites plus primaquine against dormant liver-stage forms (hypnozoites), however drug resistance confronts this regimen and threatens malaria control programs. Understanding the basis of P. vivax chloroquine resistance (CQR) will inform drug discovery and malaria control. Here we investigate the genetics of P. vivax CQR by a cross of parasites differing in drug response. Gametocytogenesis, mosquito infection, and progeny production are performed with mixed parasite populations in nonhuman primates, as methods for P. vivax cloning and in vitro cultivation remain unavailable. Linkage mapping of progeny surviving >15 mg/kg CQ identifies a 76 kb region in chromosome 1 including pvcrt, an ortholog of the Plasmodium falciparum CQR transporter gene. Transcriptional analysis supports upregulated pvcrt expression as a mechanism of CQR.
Identifiants
pubmed: 31541097
doi: 10.1038/s41467-019-12256-9
pii: 10.1038/s41467-019-12256-9
pmc: PMC6754410
doi:
Substances chimiques
Antimalarials
0
Crt-o protein, Plasmodium vivax
0
Membrane Transport Proteins
0
PfCRT protein, Plasmodium falciparum
0
Protozoan Proteins
0
Chloroquine
886U3H6UFF
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4300Subventions
Organisme : Intramural NIH HHS
ID : ZIA AI000483
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI111108
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008719
Pays : United States
Organisme : NIAID NIH HHS
ID : F30 AI143172
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007092
Pays : United States
Références
Nat Methods. 2015 Jul;12(7):631-3
pubmed: 26030447
Mol Microbiol. 2001 Jan;39(1):26-36
pubmed: 11123685
Genome Res. 2010 Sep;20(9):1297-303
pubmed: 20644199
Mol Cell Proteomics. 2014 Oct;13(10):2705-24
pubmed: 25056935
Genome Res. 2005 Jan;15(1):92-7
pubmed: 15632093
Am J Trop Med Hyg. 2000 Apr;62(4):491-5
pubmed: 11220765
Nat Methods. 2013 Jan;10(1):28-34
pubmed: 23269374
Antimicrob Agents Chemother. 2015 Nov 02;60(1):361-7
pubmed: 26525783
BMC Genomics. 2012 Mar 21;13:106
pubmed: 22435897
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Am J Trop Med Hyg. 1977 Nov;26(6 Pt 1):1116-28
pubmed: 413444
Clin Microbiol Rev. 2009 Jul;22(3):508-34
pubmed: 19597012
J Clin Invest. 2009 Sep;119(9):2496-505
pubmed: 19729847
Trans R Soc Trop Med Hyg. 1990 Jul-Aug;84(4):473
pubmed: 2091330
Genome Res. 2016 Sep;26(9):1288-99
pubmed: 27531718
Genome Biol. 2011;12(4):R33
pubmed: 21463505
Nature. 2008 Oct 9;455(7214):757-63
pubmed: 18843361
Nat Commun. 2019 Jan 22;10(1):371
pubmed: 30670687
Lancet. 2019 Jul 27;394(10195):332-343
pubmed: 31229233
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20045-50
pubmed: 21037109
J Proteome Res. 2009 Dec;8(12):5674-8
pubmed: 19848406
Trends Parasitol. 2007 Jul;23(7):332-9
pubmed: 17493873
Traffic. 2010 Feb;11(2):236-49
pubmed: 20015114
Nat Commun. 2018 Jul 3;9(1):2585
pubmed: 29968722
J Infect Dis. 2001 Jun 1;183(11):1653-61
pubmed: 11343215
Nat Genet. 2016 Aug;48(8):959-964
pubmed: 27348299
Genome Biol. 2011 Aug 11;12(8):R73
pubmed: 21835008
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8502-7
pubmed: 12799466
Mol Cell. 2000 Oct;6(4):861-71
pubmed: 11090624
Int J Parasitol. 2017 Feb;47(2-3):87-97
pubmed: 27381764
Cell Mol Life Sci. 2012 Jun;69(12):1967-95
pubmed: 22286067
Mol Biochem Parasitol. 2006 Dec;150(2):219-28
pubmed: 16987557
Malar J. 2005 Feb 11;4:11
pubmed: 15707493
Biochemistry. 2017 Oct 17;56(41):5615-5622
pubmed: 28898049
Plant Physiol. 2008 Aug;147(4):1858-73
pubmed: 18567827
Biometrics. 2003 Jun;59(2):420-9
pubmed: 12926727
J Infect Dis. 2007 Apr 15;195(8):1218-26
pubmed: 17357061
BMC Bioinformatics. 2007 May 21;8:159
pubmed: 17517127
mBio. 2018 Jan 23;9(1):
pubmed: 29362233
Lancet. 1989 Nov 18;2(8673):1183-4
pubmed: 2572903
Malar J. 2009 Apr 02;8:55
pubmed: 19341456
Trop Med Parasitol. 1992 Mar;43(1):13-6
pubmed: 1598502
Parasitology. 2000 Aug;121 ( Pt 2):121-6
pubmed: 11085231
Malar J. 2008 May 27;7:94
pubmed: 18505560
Malar J. 2008 Mar 05;7:45
pubmed: 18321384
Nat Genet. 2016 Aug;48(8):953-8
pubmed: 27348298
Nat Genet. 2011 May;43(5):491-8
pubmed: 21478889
Am J Trop Med Hyg. 2009 Feb;80(2):228-35
pubmed: 19190218
PLoS One. 2010 Dec 09;5(12):e14275
pubmed: 21151554
Sci Rep. 2017 Aug 10;7(1):7761
pubmed: 28798400
J Infect Dis. 2019 Oct 22;220(11):1738-1749
pubmed: 30668735
Curr Top Microbiol Immunol. 2008;326:277-90
pubmed: 18630758
Curr Protoc Bioinformatics. 2013;43:11.10.1-11.10.33
pubmed: 25431634
ACS Infect Dis. 2015 Aug 14;1(8):367-79
pubmed: 26719854
Nat Methods. 2012 May 30;9(6):555-66
pubmed: 22669653
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Am J Trop Med Hyg. 1978 Jul;27(4):703-17
pubmed: 99056
Mol Biol Evol. 2008 Jun;25(6):1245-52
pubmed: 18385220
PLoS One. 2014 Aug 26;9(8):e105922
pubmed: 25157811
Nat Genet. 2012 Sep;44(9):1046-50
pubmed: 22863733
Mol Biochem Parasitol. 1993 Oct;61(2):315-20
pubmed: 8264734