ImmGen report: sexual dimorphism in the immune system transcriptome.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
20 09 2019
20 09 2019
Historique:
received:
16
01
2019
accepted:
29
08
2019
entrez:
22
9
2019
pubmed:
22
9
2019
medline:
7
1
2020
Statut:
epublish
Résumé
Sexual dimorphism in the mammalian immune system is manifested as more frequent and severe infectious diseases in males and, on the other hand, higher rates of autoimmune disease in females, yet insights underlying those differences are still lacking. Here we characterize sex differences in the immune system by RNA and ATAC sequence profiling of untreated and interferon-induced immune cell types in male and female mice. We detect very few differentially expressed genes between male and female immune cells except in macrophages from three different tissues. Accordingly, very few genomic regions display differences in accessibility between sexes. Transcriptional sexual dimorphism in macrophages is mediated by genes of innate immune pathways, and increases after interferon stimulation. Thus, the stronger immune response of females may be due to more activated innate immune pathways prior to pathogen invasion.
Identifiants
pubmed: 31541153
doi: 10.1038/s41467-019-12348-6
pii: 10.1038/s41467-019-12348-6
pmc: PMC6754408
doi:
Substances chimiques
RNA
63231-63-0
Interferons
9008-11-1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4295Subventions
Organisme : NIAID NIH HHS
ID : R24 AI072073
Pays : United States
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