Molecular networking-based strategy for the discovery of polyacetylated 18-norspirostanol saponins from Trillium tschonoskii maxim.

Acetylation Animals Antineoplastic Agents, Phytogenic / chemistry Cell Line, Tumor Cell Proliferation / drug effects Dose-Response Relationship, Drug Drug Discovery Drug Screening Assays, Antitumor Humans Lipopolysaccharides / antagonists & inhibitors Macrophages / drug effects Mice Molecular Structure Nitric Oxide / antagonists & inhibitors RAW 264.7 Cells Saponins / chemistry Structure-Activity Relationship Trillium / chemistry
Anti-inflammatory effect Cytotoxicity Melanthiaceae Molecular networking Polyacetylated 18-norspirostanol saponins Trillium tschonoskii

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Dec 2019
Historique:
received: 01 02 2019
revised: 02 09 2019
accepted: 09 09 2019
pubmed: 22 9 2019
medline: 18 12 2019
entrez: 22 9 2019
Statut: ppublish

Résumé

Nine undescribed polyacetylated 18-norspirostanol saponins, trilliumosides A‒J, were obtained after a guidance based on a molecular networking strategy from the rhizomes of Trillium tschonoskii. Their structures were established by analysis of comprehensive spectroscopic data and chemical methods after their isolation in pure form. All isolated saponins were evaluated for their cytotoxicities against five selected human cancer cell lines (Huh7,A549,MCF-7,HepG2, and MOLT-4) and anti-inflammatory effects on a lipopolysaccharide (LPS)-stimulated NO production model in RAW264.7 macrophages. Trilliumoside D showed significant cytotoxicity against MOLT-4 cell lines with an IC

Identifiants

DOI: 10.1016/j.phytochem.2019.112125 PMID: 31541772
pubmed: 31541772
pii: S0031-9422(19)30094-9
doi: 10.1016/j.phytochem.2019.112125
pii:
doi:

Substances chimiques

Antineoplastic Agents, Phytogenic 0
Lipopolysaccharides 0
Saponins 0
Nitric Oxide 31C4KY9ESH

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112125

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Dan Li (D)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China; University of Chinese Academy of Sciences, Beijing, 100039, China.

Hui Liu (H)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China; University of Chinese Academy of Sciences, Beijing, 100039, China.

Wei Ni (W)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.

Wei-Lie Xiao (WL)

Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, China.

Li He (L)

Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.

Zhen-Yu Guo (ZY)

Kunming Botanee Bio-Technique Co. Ltd, Kunming, 650106, China.

Xu-Jie Qin (XJ)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China. Electronic address: qinxujie@mail.kib.ac.cn.

Hai-Yang Liu (HY)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China. Electronic address: haiyangliu@mail.kib.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Acylation › Acétylation › Molecular networking-based strategy for the...
questionsmedicales.fr › Eucaryotes › Animaux › Molecular networking-based strategy for the...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques d'origine végétale › Molecular networking-based strategy for the...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Molecular networking-based strategy for the...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Molecular networking-based strategy for the...
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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular networking-based strategy for the...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › Molecular networking-based strategy for the...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Molecular networking-based strategy for the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Molecular networking-based strategy for the...
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questionsmedicales.fr › Cellules › Cellules RAW 264.7 › Molecular networking-based strategy for the...
questionsmedicales.fr › Glucides › Hétérosides › Saponines › Molecular networking-based strategy for the...
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questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lilianae › Liliales › Melanthiaceae › Trillium › Molecular networking-based strategy for the...