Genetic susceptibility, lifestyle intervention and glycemic changes among women with prior gestational diabetes.
Adult
Biomarkers
/ blood
Blood Glucose
/ metabolism
China
Diabetes Mellitus, Type 2
/ blood
Diabetes, Gestational
/ blood
Diet, Healthy
Exercise
Female
Gene-Environment Interaction
Genetic Predisposition to Disease
Healthy Lifestyle
Humans
Insulin
/ blood
Insulin Resistance
Insulin-Secreting Cells
/ metabolism
Middle Aged
Pregnancy
Protective Factors
Receptor, Melatonin, MT2
/ genetics
Risk Assessment
Risk Factors
Risk Reduction Behavior
Time Factors
Treatment Outcome
Young Adult
tRNA Methyltransferases
/ genetics
CDKAL1
Gene-lifestyle interaction
Gestational diabetes mellitus
Insulin resistance
Lifestyle intervention
MTNR1B
Journal
Clinical nutrition (Edinburgh, Scotland)
ISSN: 1532-1983
Titre abrégé: Clin Nutr
Pays: England
ID NLM: 8309603
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
03
06
2019
revised:
18
08
2019
accepted:
30
08
2019
pubmed:
23
9
2019
medline:
17
8
2021
entrez:
23
9
2019
Statut:
ppublish
Résumé
Women with prior gestational diabetes mellitus (GDM) or high genetic susceptibility are prone to development of type 2 diabetes. We examined whether a lifestyle intervention modified the genetic effect on changes in glycemic markers among women with prior GDM. This study included 560 women with prior GDM from a randomized controlled trial, the Tianjin Gestational Diabetes Mellitus Prevention Program, who were assigned into an intervention arm (improved physical activity and healthy dietary intakes) or a control arm. We assessed associations of GDM related genetic variants in/near the CDKAL1 (rs7754840) and MTNR1B (rs10830962) genes with changes in fasting levels of glucose and insulin, β-cell function (HOMA-B) and insulin resistance (HOMA-IR) at 1 year and 2 years after the baseline. We found significant interactions between CDKAL1 variant rs7754840 and lifestyle intervention on changes in fasting insulin and HOMA-IR at 1 year (P for interactions = 0.008 and 0.006, respectively). The GDM-increasing C allele was associated with a 0.07-unit greater increase in fasting insulin (P = 0.048) and HOMA-IR (P = 0.045) in the control group, while opposite-directional associations were observed in the intervention group; women with the C allele seemed to decrease more in these glycemic markers than the non-C-carriers (both P ≤ 0.06). The interactions between the CDKAL1 genetic variant and lifestyle intervention on changes in fasting insulin (P = 0.035) and HOMA-IR (P = 0.024) remained significant over the 2-year period, even though the effects of lifestyle intervention were attenuated at 2-year. The MTNR1B variant rs10830962 did not show interaction with lifestyle intervention on changes in the glycemic markers. Healthy lifestyle intervention may be beneficial for women with the GDM predisposing CDKAL1 genetic variant in improvement of insulin resistance. ClinicalTrials.gov NCT01554358. URL OF REGISTRATION: https://clinicaltrials.gov/ct2/show/NCT01554358.
Identifiants
pubmed: 31542245
pii: S0261-5614(19)33044-4
doi: 10.1016/j.clnu.2019.08.032
pmc: PMC7062571
mid: NIHMS1539477
pii:
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Insulin
0
MTNR1B protein, human
0
Receptor, Melatonin, MT2
0
tRNA Methyltransferases
EC 2.1.1.-
CDKAL1 protein, human
EC 2.8.4.5
Banques de données
ClinicalTrials.gov
['NCT01554358']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2144-2150Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK078616
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115679
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104940
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK100790
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL126024
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL034594
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL071981
Pays : United States
Organisme : NIDDK NIH HHS
ID : UM1 DK078616
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM118430
Pays : United States
Organisme : FIC NIH HHS
ID : R21 TW010790
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK072476
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK091718
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK078616
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK100383
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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