Evaluation of a curcumin-containing mucoadhesive film for periodontal postsurgical pain control.
Analgesic
anti-inflammatory
chronic periodontitis
curcumin
mucoadhesive film
numerical rating scale
pain assessment
postoperative pain
swelling
Journal
Journal of Indian Society of Periodontology
ISSN: 0972-124X
Titre abrégé: J Indian Soc Periodontol
Pays: India
ID NLM: 101499342
Informations de publication
Date de publication:
Historique:
entrez:
24
9
2019
pubmed:
24
9
2019
medline:
24
9
2019
Statut:
ppublish
Résumé
Management of pain and discomfort is important to make the postoperative period as pleasant as possible. Nonsteroidal anti-inflammatory drugs are traditionally prescribed; however, they are associated with numerous side effects. As a result, nutraceuticals such as curcumin are widely used for its well-known safety and medicinal values. Hence, the aim of this study is to evaluate the efficacy of a curcumin mucoadhesive film for postsurgical pain control. This was a split-mouth study, consisting of 15 systemically healthy patients with 30 sites, who were randomly allocated into test (curcumin mucoadhesive film) and control (placebo mucoadhesive film) groups using coin toss method. A questionnaire was given to patients to evaluate the postoperative pain and swelling and the number of rescue medications taken. Statistical analyses used were Friedman test, Wilcoxon signed-rank test, and McNemar's test. No adverse effects were reported and healing was uneventful in all patients. The Numerical rating scale pain score showed significantly lesser pain at 1, 2, 3, 4, 5, and 24 h in the test group. Significantly more number of analgesics was consumed in total in the control group than that in the test group. Within the limitations of this study, it may be concluded that curcumin mucoadhesive film showed promising results in reducing postoperative pain and swelling over a period of 1 week, hence showing its analgesic effect after periodontal surgeries.
Sections du résumé
BACKGROUND
BACKGROUND
Management of pain and discomfort is important to make the postoperative period as pleasant as possible. Nonsteroidal anti-inflammatory drugs are traditionally prescribed; however, they are associated with numerous side effects. As a result, nutraceuticals such as curcumin are widely used for its well-known safety and medicinal values. Hence, the aim of this study is to evaluate the efficacy of a curcumin mucoadhesive film for postsurgical pain control.
MATERIALS AND METHODS
METHODS
This was a split-mouth study, consisting of 15 systemically healthy patients with 30 sites, who were randomly allocated into test (curcumin mucoadhesive film) and control (placebo mucoadhesive film) groups using coin toss method. A questionnaire was given to patients to evaluate the postoperative pain and swelling and the number of rescue medications taken. Statistical analyses used were Friedman test, Wilcoxon signed-rank test, and McNemar's test.
RESULTS
RESULTS
No adverse effects were reported and healing was uneventful in all patients. The Numerical rating scale pain score showed significantly lesser pain at 1, 2, 3, 4, 5, and 24 h in the test group. Significantly more number of analgesics was consumed in total in the control group than that in the test group.
CONCLUSION
CONCLUSIONS
Within the limitations of this study, it may be concluded that curcumin mucoadhesive film showed promising results in reducing postoperative pain and swelling over a period of 1 week, hence showing its analgesic effect after periodontal surgeries.
Identifiants
pubmed: 31543620
doi: 10.4103/jisp.jisp_700_18
pii: JISP-23-461
pmc: PMC6737849
doi:
Types de publication
Journal Article
Langues
eng
Pagination
461-468Déclaration de conflit d'intérêts
There are no conflicts of interest.
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