Conditions Under Which Glutathione Disrupts the Biofilms and Improves Antibiotic Efficacy of Both ESKAPE and Non-ESKAPE Species.
Acinetobacter baumannii
antibiotic resistance
biofilm
glutathione
thiol antioxidants
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
05
2019
accepted:
15
08
2019
entrez:
24
9
2019
pubmed:
24
9
2019
medline:
24
9
2019
Statut:
epublish
Résumé
Bacterial antibiotic resistance has increased in recent decades, raising concerns in hospital and community settings. Novel, innovative strategies are needed to eradicate bacteria, particularly within biofilms, and diminish the likelihood of recurrence. In this study, we investigated whether glutathione (GSH) can act as a biofilm disruptor, and enhance antibiotic effectiveness against various bacterial pathogens. Biological levels (10 mM) of GSH did not have a significant effect in inhibiting growth or disrupting the biofilm in four out of six species tested. However, exposure to 30 mM GSH showed >50% decrease in growth for all bacterial species, with almost 100% inhibition of
Identifiants
pubmed: 31543871
doi: 10.3389/fmicb.2019.02000
pmc: PMC6730566
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2000Références
Infect Immun. 2013 Jul;81(7):2606-15
pubmed: 23649097
Int J Gen Med. 2011 Jan 25;4:105-13
pubmed: 21403800
Jundishapur J Nat Pharm Prod. 2014 Apr 03;9(2):e15402
pubmed: 24872941
Appl Environ Microbiol. 2003 Aug;69(8):4814-22
pubmed: 12902275
FEMS Microbiol Rev. 2015 Mar;39(2):234-45
pubmed: 25725015
Microbiol Mol Biol Rev. 2003 Sep;67(3):429-53, table of contents
pubmed: 12966143
J Pharm Sci. 2006 Jul;95(7):1626-39
pubmed: 16729268
Antimicrob Agents Chemother. 2007 Oct;51(10):3471-84
pubmed: 17646423
Proc Natl Acad Sci U S A. 2014 May 20;111(20):E2100-9
pubmed: 24803433
Nat Rev Microbiol. 2010 Sep;8(9):623-33
pubmed: 20676145
J Pediatr. 2001 Jul;139(1):79-84
pubmed: 11445798
Mol Aspects Med. 2009 Feb-Apr;30(1-2):1-12
pubmed: 18796312
Curr Microbiol. 2014 May;68(5):635-41
pubmed: 24445333
Lancet Infect Dis. 2014 Aug;14(8):742-750
pubmed: 25022435
Respir Med. 2016 Aug;117:190-7
pubmed: 27492531
Antimicrob Agents Chemother. 2015 Nov 09;60(1):544-53
pubmed: 26552982
Front Microbiol. 2017 Dec 14;8:2429
pubmed: 29312161
Sci Rep. 2015 Feb 11;5:8398
pubmed: 25669133
J Appl Physiol (1985). 1993 Dec;75(6):2419-24
pubmed: 8125859
Clin Infect Dis. 2010 Jul 1;51(1):79-84
pubmed: 20504234
Lab Chip. 2015 Jan 7;15(1):23-42
pubmed: 25385289
J Chin Med Assoc. 2018 Jan;81(1):7-11
pubmed: 29042186
Int J Immunopathol Pharmacol. 2007 Jul-Sep;20(3):607-17
pubmed: 17880774
Clin Microbiol Infect. 2005 Nov;11(11):868-73
pubmed: 16216100
Infect Dis Health. 2017 Sep;22(3):117-128
pubmed: 31862087
J Drugs Dermatol. 2013 Nov;12(11):1272-7
pubmed: 24196336
Infect Immun. 2012 Jan;80(1):228-33
pubmed: 22083703
ScientificWorldJournal. 2012;2012:973436
pubmed: 22593716
Antimicrob Agents Chemother. 2001 Apr;45(4):999-1007
pubmed: 11257008
Chem Biol Interact. 1998 May 15;113(2):117-31
pubmed: 9717513
PLoS One. 2013;8(3):e58299
pubmed: 23505483
Antimicrob Agents Chemother. 2016 Jul 22;60(8):4539-51
pubmed: 27161630
FEMS Microbiol Rev. 2017 May 1;41(3):276-301
pubmed: 28369412
Prog Mol Biol Transl Sci. 2016;142:193-239
pubmed: 27571696
BMC Microbiol. 2010 May 12;10:140
pubmed: 20462423
J Inorg Biochem. 1986 Jul;27(3):191-203
pubmed: 3760859
J Bacteriol. 2009 Oct;191(19):5953-63
pubmed: 19633088
Braz J Microbiol. 2018 Jan - Mar;49(1):184-188
pubmed: 28916389
Redox Biol. 2015 Dec;6:198-205
pubmed: 26262996
Int J Immunopathol Pharmacol. 2012 Jan-Mar;25(1):207-17
pubmed: 22507333