IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update.

Adult Follow-Up Studies Gene-Environment Interaction Humans Middle Aged Twins, Dizygotic / genetics Twins, Monozygotic / genetics
Dementia early life adversity gene–environment interplay health socioeconomic status

Journal

Twin research and human genetics : the official journal of the International Society for Twin Studies
ISSN: 1832-4274
Titre abrégé: Twin Res Hum Genet
Pays: England
ID NLM: 101244624

Informations de publication

Date de publication:
12 2019
Historique:
pubmed: 24 9 2019
medline: 22 7 2020
entrez: 24 9 2019
Statut: ppublish

Résumé

The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 18 twin studies from 5 different countries (Sweden, Denmark, Finland, United States, and Australia) established to explore the nature of gene-environment (GE) interplay in functioning across the adult lifespan. Fifteen of the studies are longitudinal, with follow-up as long as 59 years after baseline. The combined data from over 76,000 participants aged 14-103 at intake (including over 10,000 monozygotic and over 17,000 dizygotic twin pairs) support two primary research emphases: (1) investigation of models of GE interplay of early life adversity, and social factors at micro and macro environmental levels and with diverse outcomes, including mortality, physical functioning and psychological functioning; and (2) improved understanding of risk and protective factors for dementia by incorporating unmeasured and measured genetic factors with a wide range of exposures measured in young adulthood, midlife and later life.

Identifiants

DOI: 10.1017/thg.2019.76 PMID: 31544729 PMC: PMC7056501
pubmed: 31544729
pii: S1832427419000768
doi: 10.1017/thg.2019.76
pmc: PMC7056501
mid: NIHMS1555531
doi:

Types de publication

Clinical Trial Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Twin Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

809-816

Subventions

Organisme : NIA NIH HHS
ID : R01 AG022982
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG018386
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059329
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG060470
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG008761
Pays : United States
Organisme : NIAAA NIH HHS
ID : K05 AA000145
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH054610
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG058068
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA009203
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG037985
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG018384
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG037985
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG039572
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG043656
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA012502
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG020166
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG010175
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056163
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG022381
Pays : United States
Organisme : NIAAA NIH HHS
ID : R37 AA012502
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG013662
Pays : United States

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Auteurs

Nancy L Pedersen (NL)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Margaret Gatz (M)

Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.

Brian K Finch (BK)

Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.

Deborah Finkel (D)

Department of Psychology, Indiana University Southeast, New Albany, IN, USA.

David A Butler (DA)

Office of Military and Veterans Health, Health and Medicine Division, The National Academies of Sciences, Engineering, and Medicine, Washington, DC, USA.

Anna Dahl Aslan (A)

Institute of Gerontology and Aging Research Network - Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Jönköping, Sweden.

Carol E Franz (CE)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.

Jaakko Kaprio (J)

Department of Public Health, Faculty of Medicine & Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.

Susan Lapham (S)

Research and Evaluation, American Institutes for Research, Washington, DC, USA.

Matt McGue (M)

Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Department of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark.

Miriam A Mosing (MA)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Jenae Neiderhiser (J)

Department of Psychology, Penn State University, University Park, PA, USA.

Marianne Nygaard (M)

The Danish Twin Registry, University of Southern Denmark, Odense C, Denmark.

Matthew Panizzon (M)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.

Carol A Prescott (CA)

Department of Psychology, University of Southern California, Los Angeles, CA, USA.

Chandra A Reynolds (CA)

Department of Psychology, University of California - Riverside, Riverside, CA, USA.

Perminder Sachdev (P)

Centre for Healthy Brain Ageing (CHeBA), University of New South Wales, Sydney, New South Wales, Australia.

Keith E Whitfield (KE)

Department of Psychology, Wayne State University, Detroit, MI, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › IGEMS: The Consortium on Interplay of Genes...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › IGEMS: The Consortium on Interplay of Genes...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Interaction entre gènes et environnement › IGEMS: The Consortium on Interplay of Genes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › IGEMS: The Consortium on Interplay of Genes...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › IGEMS: The Consortium on Interplay of Genes...
questionsmedicales.fr › Personnes › Progéniture de naissance multiple › Jumeaux › Jumeaux dizygotes › IGEMS: The Consortium on Interplay of Genes...
questionsmedicales.fr › Personnes › Progéniture de naissance multiple › Jumeaux › Jumeaux monozygotes › IGEMS: The Consortium on Interplay of Genes...