Selinexor in combination with decitabine in patients with acute myeloid leukemia: results from a phase 1 study.
Acute myeloid leukemia
clinical trials
decitabine
selinexor
Journal
Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
pubmed:
24
9
2019
medline:
28
4
2021
entrez:
24
9
2019
Statut:
ppublish
Résumé
Current treatment options for older and relapsed or refractory (R/R) acute myeloid leukemia (AML) patients are limited and represent an unmet need. Based on preclinical studies showing strong anti-leukemic effects
Identifiants
pubmed: 31545113
doi: 10.1080/10428194.2019.1665664
pmc: PMC7552944
mid: NIHMS1632123
doi:
Substances chimiques
Hydrazines
0
Triazoles
0
selinexor
31TZ62FO8F
Decitabine
776B62CQ27
Azacitidine
M801H13NRU
Banques de données
ClinicalTrials.gov
['NCT02093403']
Types de publication
Clinical Trial, Phase I
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
387-396Subventions
Organisme : NCI NIH HHS
ID : P30 CA016058
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA188269
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197734
Pays : United States
Références
N Engl J Med. 1999 Sep 30;341(14):1051-62
pubmed: 10502596
Br J Haematol. 2013 Apr;161(1):117-27
pubmed: 23373539
Leukemia. 2016 Jan;30(1):190-9
pubmed: 26202935
Bioinformatics. 2016 May 15;32(10):1557-8
pubmed: 26803155
Leukemia. 2017 Jan;31(1):143-150
pubmed: 27211268
Blood. 2017 Jun 15;129(24):3175-3183
pubmed: 28468797
Leukemia. 2016 Dec;30(12):2364-2372
pubmed: 27323910
J Clin Oncol. 2003 Dec 15;21(24):4642-9
pubmed: 14673054
J Hematol Oncol. 2016 Aug 24;9(1):73
pubmed: 27557643
J Clin Oncol. 2016 Sep 10;34(26):3166-74
pubmed: 27458288
Blood. 2015 Apr 23;125(17):2689-92
pubmed: 25716206
Cytogenet Genome Res. 2013;141(1):1-6
pubmed: 23817294
Leuk Lymphoma. 2014 Jul;55(7):1533-7
pubmed: 24144313
Blood. 2012 Aug 30;120(9):1765-73
pubmed: 22677130
Clin Cancer Res. 2016 Dec 15;22(24):6142-6152
pubmed: 27358488
Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7473-8
pubmed: 20368434
J Clin Oncol. 2016 Dec;34(34):4142-4150
pubmed: 26926685
Leuk Lymphoma. 2013 Sep;54(9):2003-7
pubmed: 23270581
Cancer Res. 2001 Oct 1;61(19):7233-9
pubmed: 11585760
Semin Cancer Biol. 2014 Aug;27:52-61
pubmed: 24631835
Blood. 2020 Jul 9;136(2):259
pubmed: 32645169