SIDT2 RNA Transporter Promotes Lung and Gastrointestinal Tumor Development.
Biological Sciences
Cancer
Cell Biology
Molecular Biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
25 Oct 2019
25 Oct 2019
Historique:
received:
06
07
2018
revised:
20
08
2019
accepted:
05
09
2019
pubmed:
24
9
2019
medline:
24
9
2019
entrez:
24
9
2019
Statut:
ppublish
Résumé
RNautophagy is a newly described type of selective autophagy whereby cellular RNAs are transported into lysosomes for degradation. This process involves the transmembrane protein SIDT2, which transports double-stranded RNA (dsRNA) across the endolysosomal membrane. We previously demonstrated that SIDT2 is a transcriptional target of p53, but its role in tumorigenesis, if any, is unclear. Unexpectedly, we show here that Sidt2
Identifiants
pubmed: 31546103
pii: S2589-0042(19)30346-3
doi: 10.1016/j.isci.2019.09.009
pmc: PMC6817685
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
14-24Subventions
Organisme : NCI NIH HHS
ID : R35 CA197591
Pays : United States
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
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