Beyond the Biological Effect of a Chemically Characterized Poplar Propolis: Antibacterial and Antiviral Activity and Comparison with Flurbiprofen in Cytokines Release by LPS-Stimulated Human Mononuclear Cells.
anti-inflammatory
antibacterial
cytokines release
flavonoids
flurbiprofen
influenza virus
neuraminidase
poplar propolis
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
21 Sep 2019
21 Sep 2019
Historique:
received:
03
09
2019
revised:
17
09
2019
accepted:
17
09
2019
entrez:
25
9
2019
pubmed:
25
9
2019
medline:
25
9
2019
Statut:
epublish
Résumé
Bee propolis, especially Euro-Asian poplar propolis, is among the most well-known natural products traditionally used to treat pharyngitis and minor wounds. The aim of this research was to investigate the pharmacological properties responsible for poplar propolis effectiveness using, for the first time, different in vitro approaches applied to a chemically characterized sample. The anti-inflammatory activity was compared with flurbiprofen by determining pro-inflammatory cytokines released by lipopolysaccharide-stimulated human peripheral blood mononuclear cells (PBMC). The antibacterial activity against Gram+ and Gram- bacteria was assessed, as well as antiviral effects on H1N1 influenza a virus. Poplar propolis (5 and 25 µg/mL) exerted a concentration-dependent anti-inflammatory activity. In this range of concentrations, propolis effect was not inferior to flurbiprofen on cytokines released by lipopolysaccharide (LPS)-stimulated human PBMC. Poplar propolis was found to upregulate IL-6 and IL-1β in non-stimulated PBMC.
Identifiants
pubmed: 31546676
pii: biomedicines7040073
doi: 10.3390/biomedicines7040073
pmc: PMC6966560
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
J Pharm Pharmacol. 2015 May;67(5):740-5
pubmed: 25644303
J Cancer Sci Ther. 2013 Oct 21;5(10):334-342
pubmed: 24466386
Evid Based Complement Alternat Med. 2013;2013:964149
pubmed: 23710243
Evid Based Complement Alternat Med. 2015;2015:595393
pubmed: 26351514
Indian J Pharmacol. 2015 Jan-Feb;47(1):11-6
pubmed: 25821304
J Ethnopharmacol. 2007 Aug 15;113(1):1-14
pubmed: 17580109
Molecules. 2017 Nov 17;22(11):null
pubmed: 29149072
Microbiol Res. 2003;158(4):353-7
pubmed: 14717457
Molecules. 2014 Nov 26;19(12):19610-32
pubmed: 25432012
Int J Gen Med. 2016 Nov 11;9:409-414
pubmed: 27956842
Cytokine. 1992 May;4(3):239-48
pubmed: 1498259
J Ethnopharmacol. 2006 Jul 19;106(3):290-302
pubmed: 16698208
PLoS One. 2015 May 14;10(5):e0125101
pubmed: 25973801
Front Pharmacol. 2017 Jun 28;8:412
pubmed: 28701955
Phytomedicine. 2009 Mar;16(2-3):97-110
pubmed: 19211237
Biochem Pharmacol. 2000 Jan 1;59(1):13-23
pubmed: 10605930
Andrologia. 2018 Feb;50(1):null
pubmed: 28470793
Exp Ther Med. 2015 May;9(5):1582-1588
pubmed: 26136862
J Chemother. 2014 Apr;26(2):86-91
pubmed: 24090970
J Pharm Biomed Anal. 2007 Nov 5;45(3):390-9
pubmed: 17935924
Acta Naturae. 2009 Jul;1(2):26-32
pubmed: 22649600
Prim Care. 1996 Dec;23(4):719-39
pubmed: 8890141
Bioorg Med Chem. 2004 Jan 2;12(1):199-215
pubmed: 14697785
J Ethnopharmacol. 2005 Aug 22;100(1-2):114-7
pubmed: 15993016
Pharmaceuticals (Basel). 2018 Nov 20;11(4):null
pubmed: 30463367