Hepatitis E Virus Entry.


Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
20 09 2019
Historique:
received: 30 08 2019
revised: 16 09 2019
accepted: 18 09 2019
entrez: 25 9 2019
pubmed: 25 9 2019
medline: 17 9 2020
Statut: epublish

Résumé

Hepatitis E virus (HEV) infection is a major cause of acute hepatitis worldwide. It is transmitted enterically but replicates in the liver. Recent studies indicate that HEV exists in two forms: naked, nonenveloped virions that are shed into feces to mediate inter-host transmission, and membrane-cloaked, quasienveloped virions that circulate in the bloodstream to mediate virus spread within a host. Both virion types are infectious, but differ in the way they infect cells. Elucidating the entry mechanism for both virion types is essential to understand HEV biology and pathogenesis, and is relevant to the development of treatments and preventions for HEV. This review summarizes the current understanding of the cell entry mechanism for these two HEV virion types.

Identifiants

pubmed: 31547135
pii: v11100883
doi: 10.3390/v11100883
pmc: PMC6832200
pii:
doi:

Substances chimiques

Receptors, Virus 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI139511
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI137912
Pays : United States

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Auteurs

Xin Yin (X)

Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA. xyin@sbpdiscovery.org.

Zongdi Feng (Z)

Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA. zongdi.feng@nationwidechildrens.org.
Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA. zongdi.feng@nationwidechildrens.org.

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Classifications MeSH