Human Ovarian Cancer Tissue Exhibits Increase of Mitochondrial Biogenesis and Cristae Remodeling.
OPA1
SIRT3
cAMP
mitochondria
mitochondrial biogenesis
ovarian cancer
oxidative phosphorylation system (OXPHOS)
prohibitins
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
12 Sep 2019
12 Sep 2019
Historique:
received:
07
08
2019
revised:
28
08
2019
accepted:
04
09
2019
entrez:
25
9
2019
pubmed:
25
9
2019
medline:
25
9
2019
Statut:
epublish
Résumé
Ovarian cancer (OC) is the most lethal gynecologic cancer characterized by an elevated apoptosis resistance that, potentially, leads to chemo-resistance in the recurrent disease. Mitochondrial oxidative phosphorylation was found altered in OC, and mitochondria were proposed as a target for therapy. Molecular evidence suggests that the deregulation of mitochondrial biogenesis, morphology, dynamics, and apoptosis is involved in carcinogenesis. However, these mitochondrial processes remain to be investigated in OC. Eighteen controls and 16 OC tissues (serous and mucinous) were collected. Enzymatic activities were performed spectrophotometrically, mitochondrial DNA (mtDNA) content was measured by real-time-PCR, protein levels were determined by Western blotting, and mitochondrial number and structure were measured by electron microscopy. Statistical analysis was performed using Student's
Identifiants
pubmed: 31547300
pii: cancers11091350
doi: 10.3390/cancers11091350
pmc: PMC6770021
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Universita degli Studi di Bari Aldo Moro
ID : Regolazione dei sistemi redox e bioenergetici cellulari in condizioni fisio-patologiche
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