Calcium Mobilization in Endothelial Cell Functions.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
12 Sep 2019
Historique:
received: 10 08 2019
revised: 02 09 2019
accepted: 06 09 2019
entrez: 25 9 2019
pubmed: 25 9 2019
medline: 6 2 2020
Statut: epublish

Résumé

Endothelial cells (ECs) constitute the innermost layer that lines all blood vessels from the larger arteries and veins to the smallest capillaries, including the lymphatic vessels. Despite the histological classification of endothelium of a simple epithelium and its homogeneous morphological appearance throughout the vascular system, ECs, instead, are extremely heterogeneous both structurally and functionally. The different arrangement of cell junctions between ECs and the local organization of the basal membrane generate different type of endothelium with different permeability features and functions. Continuous, fenestrated and discontinuous endothelia are distributed based on the specific function carried out by the organs. It is thought that a large number ECs functions and their responses to extracellular cues depend on changes in intracellular concentrations of calcium ion ([Ca

Identifiants

pubmed: 31547344
pii: ijms20184525
doi: 10.3390/ijms20184525
pmc: PMC6769945
pii:
doi:

Substances chimiques

Calcium Channels 0
Cations, Divalent 0
Calcium SY7Q814VUP

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Antonio Filippini (A)

Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Unit of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, Italy. antonio.filippini@uniroma1.it.

Antonella D'Amore (A)

Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Unit of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, Italy. antonella.damore@uniroma1.it.

Alessio D'Alessio (A)

Istituto di Istologia ed Embriologia, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario "Agostino Gemelli", IRCCS, 00168 Rome, Italy. alessio.dalessio@unicatt.it.

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