Bioactivity of hydrolysates obtained from bovine casein using artichoke (Cynara scolymus L.) proteases.
Angiotensin-Converting Enzyme Inhibitors
/ chemistry
Animals
Anti-Infective Agents
/ isolation & purification
Antihypertensive Agents
/ isolation & purification
Antioxidants
/ chemistry
Caseins
/ isolation & purification
Cattle
Cynara scolymus
/ enzymology
Molecular Weight
Peptide Hydrolases
/ metabolism
Protein Hydrolysates
/ chemistry
angiotensin-I converting enzyme (ACE) inhibitor
antimicrobial
antioxidant
artichoke
casein bioactive peptide
Journal
Journal of dairy science
ISSN: 1525-3198
Titre abrégé: J Dairy Sci
Pays: United States
ID NLM: 2985126R
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
11
03
2019
accepted:
10
07
2019
pubmed:
25
9
2019
medline:
29
1
2020
entrez:
25
9
2019
Statut:
ppublish
Résumé
The objective of this work was to obtain casein hydrolysates with aspartic proteinases present in extracts from the artichoke flower (Cynara scolymus L.) and evaluate their antioxidant, antimicrobial, and angiotensin-I converting enzyme (ACE) inhibitory activity in vitro. The casein hydrolysates produced by the action of C. scolymus had elevated antihypertensive and antioxidant activity due to their high hydrophobic peptide content (93.84, 96.58, and 90.54% at 2, 4, and 16 h of hydrolysis, respectively). Hydrolysis time and molecular weight (<3 kDa) had a significant influence on the hypertensive and antioxidant activity of the hydrolysates, which were greater at hydrolysis times of 4 and 16 h and corresponding to the <3 kDa fractions. The <3 kDa fraction of the 16 h hydrolysate had an ACE inhibitory activity with a half-maximal inhibitory concentration (IC
Identifiants
pubmed: 31548055
pii: S0022-0302(19)30822-7
doi: 10.3168/jds.2019-16596
pii:
doi:
Substances chimiques
Angiotensin-Converting Enzyme Inhibitors
0
Anti-Infective Agents
0
Antihypertensive Agents
0
Antioxidants
0
Caseins
0
Protein Hydrolysates
0
casein hydrolysate
65072-00-6
Peptide Hydrolases
EC 3.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
10711-10723Informations de copyright
Copyright © 2019 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.