Acute Megakaryocytic Leukemia.
Journal
Cold Spring Harbor perspectives in medicine
ISSN: 2157-1422
Titre abrégé: Cold Spring Harb Perspect Med
Pays: United States
ID NLM: 101571139
Informations de publication
Date de publication:
03 02 2020
03 02 2020
Historique:
pubmed:
25
9
2019
medline:
29
5
2021
entrez:
25
9
2019
Statut:
epublish
Résumé
Acute megakaryoblastic leukemia (AMKL) is a rare malignancy affecting megakaryocytes, platelet-producing cells that reside in the bone marrow. Children with Down syndrome (DS) are particularly prone to developing the disease and have a different age of onset, distinct genetic mutations, and better prognosis as compared with individuals without DS who develop the disease. Here, we discuss the contributions of chromosome 21 genes and other genetic mutations to AMKL, the clinical features of the disease, and the differing features of DS- and non-DS-AMKL. Further studies elucidating the role of chromosome 21 genes in this disease may aid our understanding of how they function in other types of leukemia, in which they are frequently mutated or differentially expressed. Although researchers have made many insights into understanding AMKL, much more remains to be learned about its underlying molecular mechanisms.
Identifiants
pubmed: 31548219
pii: cshperspect.a034884
doi: 10.1101/cshperspect.a034884
pmc: PMC6996441
pii:
doi:
Substances chimiques
GATA1 Transcription Factor
0
GATA1 protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : F31 CA216976
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA101774
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR007593
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009560
Pays : United States
Informations de copyright
Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved.
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