Comparison of propofol-ketamine versuspropofol-remifentanil in children anaesthetized for gastroscopy.
Adolescent
Anesthesia Recovery Period
Anesthetics, Combined
/ administration & dosage
Anesthetics, Dissociative
/ administration & dosage
Anesthetics, Intravenous
/ administration & dosage
Child
Child, Preschool
Female
Gastroscopy
/ methods
Humans
Ketamine
/ administration & dosage
Male
Propofol
/ administration & dosage
Remifentanil
/ administration & dosage
Single-Blind Method
Young Adult
anaesthesia
paediatric anaesthesia
paediatrics
gastroscopy
Journal
Anaesthesiology intensive therapy
ISSN: 1731-2531
Titre abrégé: Anaesthesiol Intensive Ther
Pays: Poland
ID NLM: 101472620
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
26
9
2019
medline:
29
8
2020
entrez:
26
9
2019
Statut:
ppublish
Résumé
The search for ideal anaesthesia is still an open research issue. The aim of the study was to evaluate and compare two methods of general anaesthesia with preserved own breath - propofol with ketamine and propofol with remifentanil - in children anaesthetized for gastroscopy. The study included 90 children enrolled for elective endoscopy of the upper gastrointestinal tract under general anaesthesia. The patients were randomized to one of two groups: Group K consisted of children anesthetized with propofol and ketamine, Group R included children anesthetized with propofol and remifentanil. Parameters monitored during anaesthesia were induction time, respiratory and circulatory parameters, adverse events, waking time and the child's condition after regaining consciousness. The groups differed significantly in time of induction of anaesthesia (Group K 3 ± 1 min vs. Group R 4 ± 2.5 min; P < 0.001), waking time (Group R 4 ± 4.5 min vs. Group K 6 ± 5 min; P < 0.01), condition of the child after regaining consciousness (Group R 90.9% calm, Group of K 54% confused; P < 0.001) and evaluation of test conditions in the opinion of the gastroenterologist (in favour of Group K; P < 0.05). Both methods of anaesthesia presented in the paper are safe and can be used in children to perform endoscopy. Combining propofol with ketamine allows fast induction of anaesthesia and creates very good conditions for the examination. Combining propofol with remifentanil allows fast and full return of consciousness after anaesthesia.
Sections du résumé
BACKGROUND
The search for ideal anaesthesia is still an open research issue. The aim of the study was to evaluate and compare two methods of general anaesthesia with preserved own breath - propofol with ketamine and propofol with remifentanil - in children anaesthetized for gastroscopy.
METHODS
The study included 90 children enrolled for elective endoscopy of the upper gastrointestinal tract under general anaesthesia. The patients were randomized to one of two groups: Group K consisted of children anesthetized with propofol and ketamine, Group R included children anesthetized with propofol and remifentanil. Parameters monitored during anaesthesia were induction time, respiratory and circulatory parameters, adverse events, waking time and the child's condition after regaining consciousness.
RESULTS
The groups differed significantly in time of induction of anaesthesia (Group K 3 ± 1 min vs. Group R 4 ± 2.5 min; P < 0.001), waking time (Group R 4 ± 4.5 min vs. Group K 6 ± 5 min; P < 0.01), condition of the child after regaining consciousness (Group R 90.9% calm, Group of K 54% confused; P < 0.001) and evaluation of test conditions in the opinion of the gastroenterologist (in favour of Group K; P < 0.05).
CONCLUSIONS
Both methods of anaesthesia presented in the paper are safe and can be used in children to perform endoscopy. Combining propofol with ketamine allows fast induction of anaesthesia and creates very good conditions for the examination. Combining propofol with remifentanil allows fast and full return of consciousness after anaesthesia.
Identifiants
pubmed: 31550872
pii: 37810
doi: 10.5114/ait.2019.88185
pii:
doi:
Substances chimiques
Anesthetics, Combined
0
Anesthetics, Dissociative
0
Anesthetics, Intravenous
0
Ketamine
690G0D6V8H
Remifentanil
P10582JYYK
Propofol
YI7VU623SF
Types de publication
Comparative Study
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM