Neurons Induced From Fibroblasts of c9ALS/FTD Patients Reproduce the Pathology Seen in the Central Nervous System.

RNA foci amyotrophic lateral sclerosis anti-sense oligonucleotides c9ALS/FTD c9orf72 expansion iNeurons induced neurons repeat-associated non-ATG translation

Journal

Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481

Informations de publication

Date de publication:
2019
Historique:
received: 25 01 2019
accepted: 20 08 2019
entrez: 26 9 2019
pubmed: 26 9 2019
medline: 26 9 2019
Statut: epublish

Résumé

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are incurable neurodegenerative conditions. A non-coding hexanucleotide (GGGGCC) repeat expansion in the

Identifiants

pubmed: 31551693
doi: 10.3389/fnins.2019.00935
pmc: PMC6743368
doi:

Types de publication

Journal Article

Langues

eng

Pagination

935

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Auteurs

Peter O Bauer (PO)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, United States.
Bioinova, Ltd., Prague, Czechia.
Department of Clinical Biochemistry, Hematology and Immunology, Na Homolce Hospital, Prague, Czechia.

Judith H Dunmore (JH)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, United States.

Hiroki Sasaguri (H)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, United States.

Vaclav Matoska (V)

Department of Clinical Biochemistry, Hematology and Immunology, Na Homolce Hospital, Prague, Czechia.

Classifications MeSH