The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer's Dementia.
Alzheimer’s disease
Mediterranean diet
insulin resistance
neuroinflammation and neurodegeneration
obesity
type 2 diabetes mellitus
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2019
2019
Historique:
received:
30
04
2019
accepted:
15
08
2019
entrez:
26
9
2019
pubmed:
26
9
2019
medline:
26
9
2019
Statut:
epublish
Résumé
Nowadays, Alzheimer's disease (AD) is a severe sociological and clinical problem. Since it was first described, there has been a constant increase in its incidence and, for now, there are no effective treatments since current approved medications have only shown short-term symptomatic benefits. Therefore, it is imperative to increase efforts in the search for molecules and non-pharmacological strategies that are capable of slowing or stopping the progress of the disease and, ideally, to reverse it. The amyloid cascade hypothesis based on the fundamental role of amyloid has been the central hypothesis in the last 30 years. However, since amyloid-directed treatments have shown no relevant beneficial results other theories have been postulated to explain the origin of the pathology. The brain is a highly metabolically active energy-consuming tissue in the human body. It has an almost complete dependence on the metabolism of glucose and uses most of its energy for synaptic transmission. Thus, alterations on the utilization or availability of glucose may be cause for the appearance of neurodegenerative pathologies like AD. In this review article, the hypothesis known as Type 3 Diabetes (T3D) will be evaluated by summarizing some of the data that has been reported in recent years. According to published research, the adherence over time to low saturated fatty acids diets in the context of the Mediterranean diet would reduce the inflammatory levels in brain, with a decrease in the pro-inflammatory glial activation and mitochondrial oxidative stress. In this situation, the insulin receptor pathway would be able to fine tune the mitochondrial biogenesis in neuronal cells, regulation the adenosine triphosphate/adenosine diphosphate intracellular balance, and becoming a key factor involved in the preservation of the synaptic connexions and neuronal plasticity. In addition, new targets and strategies for the treatment of AD will be considered in this review for their potential as new pharmacological or non-pharmacological approaches.
Identifiants
pubmed: 31551756
doi: 10.3389/fnagi.2019.00236
pmc: PMC6743006
doi:
Types de publication
Journal Article
Langues
eng
Pagination
236Références
J Neurosci. 1999 Sep 1;19(17):7300-8
pubmed: 10460236
Neurology. 1999 Dec 10;53(9):1937-42
pubmed: 10599761
Am J Pathol. 2000 Mar;156(3):797-805
pubmed: 10702395
J Neural Transm (Vienna). 2000;107(3):355-68
pubmed: 10821444
Science. 2000 Sep 22;289(5487):2122-5
pubmed: 11000114
Diabetes. 2002 Apr;51(4):1256-62
pubmed: 11916953
J Neural Transm (Vienna). 2002 Mar;109(3):341-60
pubmed: 11956956
J Neural Transm (Vienna). 2002 Jul;109(7-8):991-1002
pubmed: 12111436
Nat Med. 2002 Dec;8(12):1376-82
pubmed: 12426561
N Engl J Med. 2003 Jun 26;348(26):2599-608
pubmed: 12826634
Eur J Pharmacol. 2004 Apr 19;490(1-3):115-25
pubmed: 15094078
Nat Neurosci. 2005 Jan;8(1):79-84
pubmed: 15608634
J Alzheimers Dis. 2005 Feb;7(1):63-80
pubmed: 15750215
Biochem Soc Trans. 2005 Nov;33(Pt 5):1087-90
pubmed: 16246051
J Alzheimers Dis. 2006 Sep;10(1):89-109
pubmed: 16988486
J Neural Transm (Vienna). 2006 Nov;113(11):1645-58
pubmed: 17053872
FASEB J. 2008 Jan;22(1):246-60
pubmed: 17720802
Neurobiol Aging. 2010 Sep;31(9):1503-15
pubmed: 18950899
Alzheimers Dement. 2009 Jan;5(1):18-29
pubmed: 19118806
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1971-6
pubmed: 19188609
Endocrinology. 2009 Jun;150(6):2512-7
pubmed: 19372196
Nat Rev Drug Discov. 2009 May;8(5):386-98
pubmed: 19404312
J Neurochem. 2009 Aug;110(4):1129-34
pubmed: 19457065
J Neurosci. 2009 Jul 15;29(28):9078-89
pubmed: 19605645
J Alzheimers Dis. 2009;18(4):729-50
pubmed: 19661616
Hum Brain Mapp. 2010 Mar;31(3):353-64
pubmed: 19662657
J Diabetes Sci Technol. 2008 Nov;2(6):1101-13
pubmed: 19885299
Nutrition. 2010 Jul-Aug;26(7-8):823-8
pubmed: 20116211
Endocrinology. 2010 Apr;151(4):1532-40
pubmed: 20176720
Trends Biochem Sci. 2010 Sep;35(9):490-6
pubmed: 20452774
Biol Psychiatry. 2010 Nov 15;68(10):930-41
pubmed: 20692646
Aging (Albany NY). 2010 Sep;2(9):621-6
pubmed: 20834068
J Neurosci. 2010 Oct 6;30(40):13348-61
pubmed: 20926661
Neurology. 2010 Nov 30;75(22):1982-7
pubmed: 21115952
Ageing Res Rev. 2011 Apr;10(2):264-73
pubmed: 21262392
Rev Neurosci. 2011;22(4):403-10
pubmed: 21605011
J Neurosci. 2011 Jun 15;31(24):8786-802
pubmed: 21677163
J Neuroimmunol. 2011 Sep 15;238(1-2):12-8
pubmed: 21807419
J Neurochem. 2012 Feb;120(3):419-29
pubmed: 22077634
J Alzheimers Dis. 2012;29(1):151-7
pubmed: 22232009
Curr Alzheimer Res. 2012 Jan;9(1):35-66
pubmed: 22329651
J Alzheimers Dis. 2012;29(4):783-91
pubmed: 22337827
J Clin Invest. 2012 Apr;122(4):1316-38
pubmed: 22476197
Genes Dev. 2012 May 1;26(9):891-907
pubmed: 22549954
J Neural Transm (Vienna). 2013 Jan;120(1):233-52
pubmed: 22886150
Nat Commun. 2012;3:1250
pubmed: 23212379
Diabetes. 2013 Apr;62(4):1159-66
pubmed: 23223021
Trends Endocrinol Metab. 2013 Jan;24(1):40-7
pubmed: 23265946
Aging Cell. 2013 Apr;12(2):257-68
pubmed: 23362919
Diabetes. 2013 Apr;62(4):1005-6
pubmed: 23520271
Curr Pharm Des. 2013;19(38):6739-48
pubmed: 23530509
Cereb Cortex. 2014 Sep;24(9):2476-88
pubmed: 23595620
PLoS One. 2013 Apr 29;8(4):e60166
pubmed: 23637743
CNS Drugs. 2013 Jul;27(7):505-14
pubmed: 23719722
Prog Neurobiol. 2013 Sep;108:21-43
pubmed: 23850509
Eur J Pharmacol. 2013 Nov 5;719(1-3):153-160
pubmed: 23872409
Cell Rep. 2013 Aug 29;4(4):681-8
pubmed: 23954791
J Neural Transm (Vienna). 2014 Jun;121(6):611-26
pubmed: 24398779
Alzheimers Dement. 2014 Feb;10(1 Suppl):S26-32
pubmed: 24529521
Alzheimers Dement. 2014 Feb;10(1 Suppl):S76-83
pubmed: 24529528
Curr Opin Pharmacol. 2014 Feb;14:81-9
pubmed: 24565016
Front Cell Neurosci. 2014 Feb 11;8:22
pubmed: 24574966
Endocrinol Metab Clin North Am. 2014 Mar;43(1):245-67
pubmed: 24582101
Nat Rev Neurosci. 2014 May;15(5):285-99
pubmed: 24739785
Acta Neuropathol. 2014 Nov;128(5):679-89
pubmed: 25107476
Mol Neurobiol. 2016 Jan;53(1):455-471
pubmed: 25465238
Neurotherapeutics. 2015 Jan;12(1):29-41
pubmed: 25575647
Diabetes. 2015 Jun;64(6):1933-40
pubmed: 25576061
J Neural Transm (Vienna). 2015 Apr;122(4):495-7
pubmed: 25616721
EMBO Mol Med. 2015 Jan 23;7(2):190-210
pubmed: 25617315
J Neurochem. 2015 Apr;133(1):125-33
pubmed: 25640170
J Neural Transm (Vienna). 2015 Apr;122(4):499-504
pubmed: 25673434
Sci Rep. 2015 Mar 12;5:9035
pubmed: 25762148
J Alzheimers Dis. 2015;46(4):843-8
pubmed: 25869787
J Clin Invest. 2015 Jun;125(6):2463-7
pubmed: 25938784
Pediatrics. 2015 Jun;135(6):1074-81
pubmed: 25963004
Mol Neurobiol. 2016 May;53(4):2320-38
pubmed: 25976367
Horm Behav. 2015 Jun;72:68-77
pubmed: 25989597
Biochim Biophys Acta. 2015 Sep;1852(9):1687-99
pubmed: 26003667
Trends Pharmacol Sci. 2015 Jul;36(7):461-70
pubmed: 26022934
Curr Alzheimer Res. 2015;12(8):723-35
pubmed: 26159189
Nat Rev Neurol. 2015 Aug;11(8):457-70
pubmed: 26195256
Diabetes. 2015 Nov;64(11):3927-36
pubmed: 26216852
Nutrients. 2015 Sep 01;7(9):7332-57
pubmed: 26340637
Curr Diab Rep. 2015 Nov;15(11):89
pubmed: 26370700
J Alzheimers Dis. 2015;46(4):1111-27
pubmed: 26402637
Q J Exp Psychol (Hove). 2016 Nov;69(11):2305-16
pubmed: 26447832
J Physiol. 2016 Jan 15;594(2):267-79
pubmed: 26608096
Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15731-6
pubmed: 26644559
Alzheimers Dement. 2016 Jan;12(1):60-4
pubmed: 26710325
Metab Brain Dis. 2016 Jun;31(3):497-515
pubmed: 26883429
Curr Opin Behav Sci. 2016 Jun 1;9:47-54
pubmed: 26955646
J Nutr. 2016 Mar 9;:
pubmed: 26962178
Biochim Biophys Acta. 2016 Jun;1860(6):1291-8
pubmed: 26970498
Curr Opin Behav Sci. 2016 Jun;9:40-46
pubmed: 26998507
EMBO Mol Med. 2016 Jun 01;8(6):595-608
pubmed: 27025652
Rev Invest Clin. 2016 Mar-Apr;68(2):53-8
pubmed: 27103040
Diabetologia. 2016 Jul;59(7):1513-1523
pubmed: 27138913
J Exp Med. 2016 Jul 25;213(8):1375-85
pubmed: 27432942
J Neuroinflammation. 2016 Aug 26;13(1):206
pubmed: 27566530
J Alzheimers Dis. 2016 Jul 14;54(1):233-51
pubmed: 27567882
Biochim Biophys Acta Mol Basis Dis. 2017 May;1863(5):1078-1089
pubmed: 27567931
Alzheimers Dement. 2016 Apr;12(4):459-509
pubmed: 27570871
Behav Brain Res. 2017 Jan 1;316:234-244
pubmed: 27591966
Sci Rep. 2016 Oct 05;6:34790
pubmed: 27703224
J Intern Med. 2016 Nov;280(5):430-442
pubmed: 27739227
Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):499-508
pubmed: 27771511
Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12292-12297
pubmed: 27791018
Front Biosci (Landmark Ed). 2017 Jan 1;22:795-814
pubmed: 27814647
Mech Ageing Dev. 2017 Mar;162:38-45
pubmed: 27863851
Drugs. 2017 Jan;77(1):47-65
pubmed: 27988872
Mol Psychiatry. 2017 Sep;22(9):1327-1334
pubmed: 28044060
Cold Spring Harb Perspect Biol. 2017 Jun 1;9(6):null
pubmed: 28062560
Sci Rep. 2017 Feb 06;7:41795
pubmed: 28165482
Mol Metab. 2016 Dec 08;6(2):174-184
pubmed: 28180059
Yonsei Med J. 2017 May;58(3):479-488
pubmed: 28332351
Mol Cell Neurosci. 2017 Jul;82:23-34
pubmed: 28438696
Exp Biol Med (Maywood). 2017 Jul;242(13):1335-1344
pubmed: 28534431
Neurochem Int. 2017 Sep;108:296-302
pubmed: 28551028
eNeuro. 2017 Jun 13;4(3):
pubmed: 28612048
J Exp Med. 2017 Aug 7;214(8):2257-2269
pubmed: 28652303
J Endocrinol. 2017 Oct;235(1):49-67
pubmed: 28710249
Mol Neurobiol. 2018 Jun;55(6):4885-4895
pubmed: 28752224
J Exp Med. 2017 Sep 4;214(9):2591-2610
pubmed: 28765400
FASEB J. 2017 Dec;31(12):5409-5418
pubmed: 28808140
Biochem Biophys Res Commun. 2017 Nov 4;493(1):731-736
pubmed: 28865961
Adv Neurobiol. 2017;19:117-150
pubmed: 28933063
Alzheimers Dement. 2018 Feb;14(2):178-186
pubmed: 28943197
Neuron. 2017 Sep 27;96(1):115-129.e5
pubmed: 28957663
Nat Rev Neurol. 2017 Sep 29;13(10):612-623
pubmed: 28960209
Int J Obes (Lond). 2018 Mar;42(3):391-397
pubmed: 28990588
Brain Res. 2018 Jan 1;1678:64-74
pubmed: 29050859
Brain. 2017 Dec 1;140(12):3269-3285
pubmed: 29053786
Alzheimers Dement. 2018 Mar;14(3):318-329
pubmed: 29055815
Mol Psychiatry. 2018 Sep;23(9):1948-1956
pubmed: 29086767
Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):263-273
pubmed: 29107091
Neuropharmacology. 2018 Mar 15;131:440-452
pubmed: 29111385
Clin Nutr. 2019 Feb;38(1):438-443
pubmed: 29233588
J Alzheimers Dis. 2018;62(3):1223-1240
pubmed: 29254093
Mol Neurobiol. 2018 Sep;55(9):7327-7339
pubmed: 29404958
J Alzheimers Dis. 2018;64(s1):S405-S426
pubmed: 29562518
J Alzheimers Dis. 2018;62(3):1381-1390
pubmed: 29562538
CNS Neurosci Ther. 2018 Sep;24(9):763-774
pubmed: 29691988
PLoS One. 2018 May 24;13(5):e0196983
pubmed: 29795582
Endocr Rev. 2018 Oct 1;39(5):719-738
pubmed: 29905825
Alzheimers Dement (N Y). 2018 May 03;4:195-214
pubmed: 29955663
Nutrients. 2018 Aug 21;10(9):null
pubmed: 30134549
Nat Rev Neurol. 2018 Nov;14(11):653-666
pubmed: 30291317
Sci Rep. 2018 Oct 31;8(1):16128
pubmed: 30382190
Alzheimers Dement (N Y). 2018 Oct 14;4:535-541
pubmed: 30386818
Nutrients. 2018 Nov 03;10(11):null
pubmed: 30400288
Front Cell Neurosci. 2018 Oct 23;12:373
pubmed: 30405355
Expert Opin Investig Drugs. 2019 Jan;28(1):93-97
pubmed: 30480461
CNS Drugs. 2019 Mar;33(3):209-223
pubmed: 30511349
Alzheimers Dement. 2019 Mar;15(3):410-417
pubmed: 30527596
Nat Med. 2019 Jan;25(1):165-175
pubmed: 30617325
Neurobiol Aging. 2019 Apr;76:45-52
pubmed: 30682676
Front Neurosci. 2019 Jan 14;12:1027
pubmed: 30692905
Am J Clin Nutr. 2019 Feb 1;109(2):361-368
pubmed: 30698630
Mol Neurobiol. 2019 Sep;56(9):6156-6167
pubmed: 30734227
Lab Invest. 2019 Jul;99(7):958-970
pubmed: 30760863
J Alzheimers Dis. 2019;68(2):657-668
pubmed: 30775986
Am J Clin Nutr. 2019 Mar 1;109(3):626-634
pubmed: 30796776
Front Psychiatry. 2019 Feb 08;10:15
pubmed: 30800078
Front Cell Neurosci. 2019 Feb 05;13:17
pubmed: 30804755
Exp Neurol. 2019 Jun;316:1-11
pubmed: 30930096