Neurobiology and Therapeutic Potential of Cyclooxygenase-2 (COX-2) Inhibitors for Inflammation in Neuropsychiatric Disorders.
autism spectrum disorder
bipolar disorder
cyclooxygenase-2 inhibitors
depression
inflammation
obsessive compulsive disorder
psychiatry
schizophrenia
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2019
2019
Historique:
received:
17
09
2018
accepted:
30
07
2019
entrez:
26
9
2019
pubmed:
26
9
2019
medline:
26
9
2019
Statut:
epublish
Résumé
Neuropsychiatric disorders, such as depression, bipolar disorder, schizophrenia, obsessive-compulsive disorder, and neurodevelopmental disorders such as autism spectrum disorder, are associated with significant illness burden. Accumulating evidence supports an association between these disorders and inflammation. Consequently, anti-inflammatory agents, such as the cyclooxygenase-2 inhibitors, represent a novel avenue to prevent and treat neuropsychiatric illness. In this paper, we first review the role of inflammation in psychiatric pathophysiology including inflammatory cytokines' influence on neurotransmitters, the hypothalamic-pituitary-adrenal axis, and microglial mechanisms. We then discuss how cyclooxygenase-2-inhibitors influence these pathways with potential therapeutic benefit, with a focus on celecoxib, due to its superior safety profile. A search was conducted in PubMed, Embase, and PsychINFO databases, in addition to Clinicaltrials.gov and the Stanley Medical Research Institute trial registries. The results were presented as a narrative review. Currently available outcomes for randomized controlled trials up to November 2017 are also discussed. The evidence reviewed here suggests cyclooxygenase-2 inhibitors, and in particular celecoxib, may indeed assist in treating the symptoms of neuropsychiatric disorders; however, further studies are required to assess appropriate illness stage-related indication.
Identifiants
pubmed: 31551825
doi: 10.3389/fpsyt.2019.00605
pmc: PMC6738329
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
605Commentaires et corrections
Type : CommentIn
Références
Nat Med. 1999 Jun;5(6):698-701
pubmed: 10371510
Cell Tissue Res. 1999 May;296(2):235-46
pubmed: 10382268
Lancet. 1999 Oct 2;354(9185):1153-8
pubmed: 10513708
Brain Res. 1999 Oct 2;843(1-2):118-29
pubmed: 10528118
Oncogene. 1999 Dec 20;18(55):7908-16
pubmed: 10630643
Neuropsychopharmacology. 2000 Apr;22(4):370-9
pubmed: 10700656
N Engl J Med. 2000 Mar 23;342(12):836-43
pubmed: 10733371
Schizophr Res. 2000 Apr 7;42(2):157-64
pubmed: 10742653
J Clin Psychiatry. 2000;61 Suppl 6:4-6
pubmed: 10775017
Am J Psychiatry. 2000 May;157(5):683-94
pubmed: 10784457
J Biol Chem. 2000 Sep 8;275(36):28028-32
pubmed: 10827178
Behav Brain Res. 2000 Jun 15;111(1-2):93-8
pubmed: 10840135
N Engl J Med. 2000 Oct 19;343(16):1139-47
pubmed: 11036119
Br J Psychiatry. 2000 Nov;177:390-5
pubmed: 11059990
N Engl J Med. 2000 Nov 23;343(21):1520-8, 2 p following 1528
pubmed: 11087881
J Psychiatr Res. 2000 Nov-Dec;34(6):369-82
pubmed: 11165304
Neurochem Int. 2001 May;38(6):485-501
pubmed: 11248397
Ann N Y Acad Sci. 2000;917:608-17
pubmed: 11268389
Arch Gen Psychiatry. 2001 May;58(5):445-52
pubmed: 11343523
Am J Psychiatry. 2001 Aug;158(8):1316-9
pubmed: 11481169
N Engl J Med. 2001 Aug 9;345(6):433-42
pubmed: 11496855
Pediatrics. 2001 Oct;108(4):E58
pubmed: 11581466
J Clin Psychopharmacol. 2001 Oct;21(5):488-92
pubmed: 11593074
Psychosom Med. 2002 Jan-Feb;64(1):52-60
pubmed: 11818586
BMJ. 2002 Feb 16;324(7334):393-6
pubmed: 11850369
Trends Neurosci. 2002 Mar;25(3):154-9
pubmed: 11852148
Prog Neuropsychopharmacol Biol Psychiatry. 2002 Jan;26(1):33-9
pubmed: 11853116
J Pharmacol Exp Ther. 2002 May;301(2):494-500
pubmed: 11961048
Inflamm Res. 2002 Mar;51(3):154-9
pubmed: 12005206
Brain Res. 2002 Jun 21;941(1-2):1-10
pubmed: 12031542
J Neurotrauma. 2002 May;19(5):627-38
pubmed: 12042097
Am J Psychiatry. 2002 Jun;159(6):1029-34
pubmed: 12042193
Arch Gen Psychiatry. 2002 Jul;59(7):592-6
pubmed: 12090811
J Neurosci Res. 2002 May 1;68(3):337-43
pubmed: 12111864
J Pharmacol Exp Ther. 2002 Sep;302(3):846-52
pubmed: 12183639
Nat Rev Drug Discov. 2002 Aug;1(8):609-20
pubmed: 12402501
Biol Psychiatry. 2003 Jan 15;53(2):157-65
pubmed: 12547472
J Endotoxin Res. 2003;9(1):3-24
pubmed: 12691614
Neuropsychopharmacology. 2003 Aug;28(8):1515-20
pubmed: 12799618
J Clin Invest. 2003 Jun;111(12):1805-12
pubmed: 12813013
Int J Methods Psychiatr Res. 2003;12(1):3-21
pubmed: 12830306
Am J Psychiatry. 2003 Sep;160(9):1554-65
pubmed: 12944327
Int Immunopharmacol. 2003 Oct;3(10-11):1519-28
pubmed: 12946449
Biochem Biophys Res Commun. 1992 Sep 16;187(2):1123-7
pubmed: 1382414
Vaccine. 2003 Dec 8;22(1):1-6
pubmed: 14604564
J Biol Chem. 1992 Dec 25;267(36):25934-8
pubmed: 1464605
J ECT. 2003 Dec;19(4):183-8
pubmed: 14657769
Int J Oncol. 2004 Mar;24(3):505-12
pubmed: 14767534
Curr Opin Pharmacol. 2004 Feb;4(1):12-7
pubmed: 15018833
N Engl J Med. 2004 Apr 1;350(14):1387-97
pubmed: 15070788
Pediatrics. 2004 May;113(5):e472-86
pubmed: 15121991
Dig Dis Sci. 2004 Mar;49(3):492-7
pubmed: 15139504
Lancet. 2004 Aug 21-27;364(9435):665-74
pubmed: 15325831
Lancet. 2004 Aug 21-27;364(9435):675-84
pubmed: 15325832
J Affect Disord. 2004 Oct 15;82(2):309-13
pubmed: 15488263
Ann Neurol. 2005 Jan;57(1):67-81
pubmed: 15546155
Eur Arch Psychiatry Clin Neurosci. 2005 Apr;255(2):149-51
pubmed: 15549344
Prog Neuropsychopharmacol Biol Psychiatry. 2005 Feb;29(2):201-17
pubmed: 15694227
Mol Psychiatry. 2005 May;10(5):426-8
pubmed: 15700047
Schizophr Res. 1992 Mar;6(3):181-92
pubmed: 1571312
N Engl J Med. 2005 Mar 17;352(11):1092-102
pubmed: 15713943
J Psychiatr Res. 2005 May;39(3):311-23
pubmed: 15725430
Viral Immunol. 2005;18(1):41-78
pubmed: 15802953
Brain Behav Immun. 2005 Jul;19(4):345-50
pubmed: 15944074
Biol Psychiatry. 2005 Jun 15;57(12):1594-6
pubmed: 15953498
Pharmacol Biochem Behav. 2005 Jul;81(3):688-93
pubmed: 15982728
Brain Res Mol Brain Res. 2005 Oct 3;139(2):217-24
pubmed: 16055227
J Clin Psychiatry. 2005;66 Suppl 7:5-13
pubmed: 16124836
Gut. 2005 Nov;54(11):1509-14
pubmed: 16227351
AIDS. 2005 Oct;19 Suppl 3:S174-8
pubmed: 16251815
Am J Physiol. 1992 Jul;263(1 Pt 2):F97-102
pubmed: 1636747
Lancet. 2006 Jan 7;367(9504):29-35
pubmed: 16399150
Trends Neurosci. 2006 Feb;29(2):68-74
pubmed: 16406093
J Affect Disord. 2006 Feb;90(2-3):263-7
pubmed: 16410025
Pediatrics. 2006 Feb;117(2):e320-1
pubmed: 16452338
J Neuroimmunol. 2006 Mar;172(1-2):156-65
pubmed: 16457895
J Neural Transm (Vienna). 2006 Oct;113(10):1355-65
pubmed: 16465454
Schizophr Bull. 2006 Apr;32(2):200-2
pubmed: 16469941
Mol Psychiatry. 2006 Jul;11(7):680-4
pubmed: 16491133
Am J Psychiatry. 2006 Mar;163(3):521-8
pubmed: 16513876
Brain Behav Immun. 2006 Nov;20(6):532-45
pubmed: 16580814
Dialogues Clin Neurosci. 2006;8(1):71-8
pubmed: 16640116
Int Clin Psychopharmacol. 2006 Jul;21(4):219-25
pubmed: 16687993
Br J Psychiatry. 2006 Jun;188:510-8
pubmed: 16738340
J Neurochem. 2006 Aug;98(3):801-11
pubmed: 16787416
J Psychiatr Res. 2007 Apr-Jun;41(3-4):326-31
pubmed: 16870211
J Affect Disord. 2007 Feb;98(1-2):143-51
pubmed: 16952400
Nat Rev Neurosci. 2007 Jan;8(1):57-69
pubmed: 17180163
J Neuroinflammation. 2007 Jan 05;4:3
pubmed: 17207275
Schizophr Res. 2007 Feb;90(1-3):179-85
pubmed: 17208413
Brain Behav Immun. 2007 May;21(4):374-83
pubmed: 17360153
Bipolar Disord. 2007 Feb-Mar;9(1-2):114-25
pubmed: 17391355
J Neuropathol Exp Neurol. 2007 May;66(5):363-71
pubmed: 17483693
Schizophr Res. 2007 Jul;93(1-3):261-5
pubmed: 17490859
Mediators Inflamm. 2007;2007:65704
pubmed: 17497035
Eur Psychiatry. 2007 Sep;22(6):380-6
pubmed: 17524626
South Med J. 2007 May;100(5):494-8
pubmed: 17534086
Expert Rev Neurother. 2007 Jul;7(7):789-96
pubmed: 17610386
Head Neck. 2008 Jan;30(1):67-74
pubmed: 17615567
Int Rev Neurobiol. 2007;82:265-75
pubmed: 17678966
Adv Exp Med Biol. 1991;294:345-58
pubmed: 1772073
Ann N Y Acad Sci. 2007 Jun;1107:79-91
pubmed: 17804535
Bipolar Disord. 2007 Nov;9(7):743-53
pubmed: 17988365
Biol Psychiatry. 2008 Apr 15;63(8):801-8
pubmed: 18005941
Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec;77(5-6):239-46
pubmed: 18042366
Nat Rev Neurosci. 2008 Jan;9(1):46-56
pubmed: 18073775
Hum Psychopharmacol. 2008 Mar;23(2):87-94
pubmed: 18172906
Mol Psychiatry. 2009 May;14(5):511-22
pubmed: 18195714
Mol Cell Endocrinol. 2008 Mar 26;285(1-2):51-61
pubmed: 18316157
J ECT. 2008 Mar;24(1):88-91
pubmed: 18379341
Prim Care Companion J Clin Psychiatry. 2008;10(2):91-6
pubmed: 18458732
Biol Psychiatry. 2008 Nov 1;64(9):820-2
pubmed: 18534557
Neuro Endocrinol Lett. 2008 Jun;29(3):287-91
pubmed: 18580840
Lancet. 2008 Jul 12;372(9633):117-26
pubmed: 18620949
Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10537-40
pubmed: 18650379
Behav Brain Res. 2008 Dec 12;194(2):138-45
pubmed: 18655807
Pediatrics. 2008 Aug;122(2):e438-45
pubmed: 18676531
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Dec 12;32(8):1789-92
pubmed: 18718498
Int J Methods Psychiatr Res. 2008;17(3):121-40
pubmed: 18763692
Brain Behav Immun. 2009 Feb;23(2):217-24
pubmed: 18835437
Biol Psychiatry. 2009 Mar 15;65(6):481-8
pubmed: 19058794
Clin Infect Dis. 2009 Feb 15;48(4):456-61
pubmed: 19128068
J Neurosci. 2009 Jan 7;29(1):14-22
pubmed: 19129380
Curr Med Chem. 2009;16(2):157-70
pubmed: 19149568
Biol Psychiatry. 2009 May 1;65(9):732-41
pubmed: 19150053
Psychosom Med. 2009 Feb;71(2):171-86
pubmed: 19188531
J Affect Disord. 2009 Aug;116(3):214-7
pubmed: 19251324
Trends Pharmacol Sci. 2009 Apr;30(4):174-81
pubmed: 19269697
J Immunother. 2009 Jan;32(1):22-8
pubmed: 19307990
Schizophr Res. 2009 May;110(1-3):1-23
pubmed: 19328655
Autism Res. 2008 Oct;1(5):275-83
pubmed: 19343198
Neuropsychobiology. 2009;59(2):123-9
pubmed: 19390223
J Endocrinol. 2009 Jul;202(1):87-97
pubmed: 19406955
Curr Pharm Des. 2009;15(14):1563-86
pubmed: 19442174
J Psychiatr Res. 2009 Sep;43(14):1171-4
pubmed: 19473667
Mol Psychiatry. 2010 Apr;15(4):384-92
pubmed: 19488045
Depress Anxiety. 2009;26(7):607-11
pubmed: 19496103
Psychiatry Clin Neurosci. 2009 Aug;63(4):516-20
pubmed: 19497000
J Clin Psychiatry. 2009 Aug;70(8):1078-90
pubmed: 19497250
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Aug 31;33(6):1058-63
pubmed: 19505522
Psychiatry Clin Neurosci. 2009 Jun;63(3):257-65
pubmed: 19579286
Lancet. 2009 Aug 22;374(9690):635-45
pubmed: 19700006
J Psychiatr Res. 2010 Feb;44(3):183-92
pubmed: 19747693
J Cereb Blood Flow Metab. 2010 Jan;30(1):230-41
pubmed: 19794397
J Nucl Med. 2009 Nov;50(11):1801-7
pubmed: 19837763
J Cereb Blood Flow Metab. 2010 Feb;30(2):370-80
pubmed: 19844242
Ann N Y Acad Sci. 2009 Oct;1179:144-52
pubmed: 19906237
Mol Psychiatry. 2010 Apr;15(4):393-403
pubmed: 19918244
Biol Psychiatry. 2010 Mar 1;67(5):446-57
pubmed: 20015486
Expert Rev Neurother. 2010 Jan;10(1):59-76
pubmed: 20021321
J Lipid Res. 2010 May;51(5):1049-56
pubmed: 20040630
Psychiatry Investig. 2008 Dec;5(4):232-8
pubmed: 20046343
Psychiatry Res. 2010 Mar 30;176(1):1-7
pubmed: 20067853
Cell Signal. 2010 Jul;22(7):977-83
pubmed: 20096353
Am J Psychiatry. 2010 Mar;167(3):261-80
pubmed: 20123911
Curr Opin Neurol. 2010 Apr;23(2):111-7
pubmed: 20160651
J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S3-23
pubmed: 20176265
J Am Acad Dermatol. 2010 May;62(5):812-8
pubmed: 20219265
Biol Psychiatry. 2010 Jun 1;67(11):1097-105
pubmed: 20303066
Int J Neuropsychopharmacol. 2010 Aug;13(7):943-50
pubmed: 20350336
Psychoneuroendocrinology. 2011 Apr;36(3):415-25
pubmed: 20399565
J Am Acad Dermatol. 2010 Sep;63(3):457-65
pubmed: 20462664
Schizophr Res. 2010 Aug;121(1-3):118-24
pubmed: 20570110
Int J Neuropsychopharmacol. 2010 Nov;13(10):1369-81
pubmed: 20633309
Methods Mol Biol. 2010;644:181-8
pubmed: 20645174
Biol Psychiatry. 2010 Aug 15;68(4):368-76
pubmed: 20674603
Isr J Psychiatry Relat Sci. 2010;47(1):56-63
pubmed: 20686200
Brain Behav Immun. 2011 Jan;25(1):40-5
pubmed: 20705131
Brain Res Rev. 2011 Jan 7;66(1-2):152-73
pubmed: 20883721
Psychosomatics. 2010 Nov-Dec;51(6):466-73
pubmed: 21051677
Sci Signal. 2010 Nov 09;3(147):jc8
pubmed: 21062990
J Biomed Biotechnol. 2011;2011:457079
pubmed: 21127706
J Affect Disord. 2011 Jun;131(1-3):143-9
pubmed: 21167607
Curr Immunol Rev. 2010 Aug;6(3):205-212
pubmed: 21170282
J Affect Disord. 2011 Jun;131(1-3):388-92
pubmed: 21183225
Arch Gen Psychiatry. 2011 Jan;68(1):90-100
pubmed: 21199968
J Biol Chem. 1990 Oct 5;265(28):16737-40
pubmed: 2120205
Psychiatry Res. 2011 Oct 30;189(3):403-6
pubmed: 21329988
Pharmacol Ther. 2011 May;130(2):226-38
pubmed: 21334376
J Neurochem. 1990 Oct;55(4):1327-39
pubmed: 2144582
J Affect Disord. 2012 Apr;138(1-2):9-18
pubmed: 21511342
Br J Dermatol. 2011 Sep;165(3):593-9
pubmed: 21517800
Biol Psychiatry. 2011 Oct 1;70(7):663-71
pubmed: 21641581
Am J Geriatr Psychiatry. 2012 Jun;20(6):505-13
pubmed: 21775876
Science. 2011 Sep 9;333(6048):1456-8
pubmed: 21778362
Diabetologia. 2011 Oct;54(10):2483-93
pubmed: 21789690
Neuropsychopharmacology. 2011 Nov;36(12):2452-9
pubmed: 21796103
Neurosci Res. 2011 Nov;71(3):210-8
pubmed: 21802455
J Neuroinflammation. 2011 Aug 10;8:94
pubmed: 21831269
Int J Environ Res Public Health. 2011 Jul;8(7):2980-3018
pubmed: 21845170
Brain Behav Immun. 2012 Mar;26(3):383-92
pubmed: 21906670
Psychol Med. 2012 Apr;42(4):671-81
pubmed: 21910935
Neuropsychopharmacology. 2012 Jan;37(1):137-62
pubmed: 21918508
PLoS One. 2011;6(9):e24691
pubmed: 21935439
Trends Cogn Sci. 2012 Jan;16(1):43-51
pubmed: 22138231
PLoS One. 2011;6(12):e28330
pubmed: 22164271
Am J Psychiatry. 2011 Dec;168(12):1303-10
pubmed: 22193673
Arch Gen Psychiatry. 2012 Jan;69(1):16-26
pubmed: 22213785
J Affect Disord. 2012 May;138(3):360-6
pubmed: 22331023
Psychiatry Res. 2012 Jun 30;198(1):74-80
pubmed: 22386567
Front Pharmacol. 2012 Mar 09;3:41
pubmed: 22408626
J Clin Invest. 2012 Apr;122(4):1164-71
pubmed: 22466658
J Autism Dev Disord. 2012 Dec;42(12):2569-84
pubmed: 22466688
Curr Psychiatry Rep. 2012 Jun;14(3):220-8
pubmed: 22477442
Dev Neurobiol. 2012 Oct;72(10):1272-6
pubmed: 22488761
Horm Behav. 2012 Aug;62(3):202-9
pubmed: 22504306
J Affect Disord. 2012 Dec 10;141(2-3):308-14
pubmed: 22516310
Neuropsychopharmacology. 2012 Aug;37(9):2093-100
pubmed: 22549115
Bipolar Disord. 2012 Jun;14(4):313-25
pubmed: 22631617
Bipolar Disord. 2012 Jun;14(4):356-74
pubmed: 22631620
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):143-8
pubmed: 22691715
J Affect Disord. 2013 Jan 10;144(1-2):16-27
pubmed: 22749156
Metab Brain Dis. 2012 Dec;27(4):405-13
pubmed: 22773310
Psychopharmacology (Berl). 2013 Jan;225(1):51-9
pubmed: 22782459
Recent Pat Antiinfect Drug Discov. 2013 Apr;8(1):18-26
pubmed: 22812614
Ann N Y Acad Sci. 2012 Jul;1261:55-63
pubmed: 22823394
CNS Drugs. 2012 Oct 1;26(10):883-92
pubmed: 22873680
Int Psychogeriatr. 2012 Dec;24(12):1878-90
pubmed: 22874475
Eur Neuropsychopharmacol. 2013 Jul;23(7):594-601
pubmed: 22921470
J Clin Psychiatry. 2012 Aug;73(8):1128-38
pubmed: 22967776
Expert Rev Neurother. 2012 Sep;12(9):1143-61
pubmed: 23039393
Mol Psychiatry. 2013 Jun;18(6):692-9
pubmed: 23089630
Trends Pharmacol Sci. 2013 Feb;34(2):136-43
pubmed: 23123095
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Apr 5;42:135-45
pubmed: 23178231
Curr Opin Psychiatry. 2013 Jan;26(1):19-26
pubmed: 23196997
J Neuroinflammation. 2012 Dec 11;9:265
pubmed: 23231720
JAMA Psychiatry. 2013 Feb;70(2):176-84
pubmed: 23266538
Pharmacol Rev. 2013 Jan 08;65(1):105-42
pubmed: 23300133
Mol Psychiatry. 2013 Feb;18(2):133
pubmed: 23344565
Biol Psychiatry. 2013 Jul 1;74(1):15-25
pubmed: 23419545
Depress Anxiety. 2013 Apr;30(4):297-306
pubmed: 23468190
J Neuroinflammation. 2013 Apr 01;10:43
pubmed: 23547920
J Neuroinflammation. 2013 Apr 05;10:45
pubmed: 23561827
Neuroscience. 2013 Aug 29;246:199-229
pubmed: 23644052
N Engl J Med. 2013 May 16;368(20):1907-17
pubmed: 23675659
JAMA Psychiatry. 2013 Aug;70(8):812-20
pubmed: 23760347
J Psychiatr Res. 2013 Sep;47(9):1119-33
pubmed: 23768870
Rev Sci Tech. 2013 Apr;32(1):117-25
pubmed: 23837370
Brain Behav Immun. 2013 Oct;33:131-8
pubmed: 23850810
Neuropsychopharmacology. 2013 Aug;38(9):1607-8
pubmed: 23857540
PLoS One. 2013 Jul 09;8(7):e69524
pubmed: 23874970
Psychoneuroendocrinology. 2013 Nov;38(11):2394-404
pubmed: 23890984
Eur Heart J. 2013 Dec;34(45):3478-90a
pubmed: 23956253
Am J Med. 2013 Nov;126(11):1017.e11-8
pubmed: 23993259
Brain Behav Immun. 2014 Jan;35:70-6
pubmed: 24016864
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:79-85
pubmed: 24056287
Oxid Med Cell Longev. 2013;2013:104024
pubmed: 24089628
BMC Med. 2013 Sep 12;11:200
pubmed: 24228900
Mol Psychiatry. 2014 Jul;19(7):750-1
pubmed: 24342989
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Aug 4;53:23-34
pubmed: 24468642
Swiss Med Wkly. 2014 Feb 19;144:w13880
pubmed: 24554598
Neuroimmunomodulation. 2014;21(2-3):117-22
pubmed: 24557044
Immunol Lett. 2014 Jul;160(1):17-22
pubmed: 24698730
Brain Behav Immun. 2014 Aug;40:219-25
pubmed: 24703991
ACS Chem Neurosci. 2014 Jun 18;5(6):459-67
pubmed: 24786695
Soc Psychiatry Psychiatr Epidemiol. 2014 Jun;49(6):841-9
pubmed: 24789456
JAMA Psychiatry. 2014 May;71(5):573-81
pubmed: 24806211
Int Clin Psychopharmacol. 2014 Nov;29(6):344-50
pubmed: 24850229
J Neuroinflammation. 2014 Jun 03;11:98
pubmed: 24889886
Mol Psychiatry. 2015 Apr;20(4):440-6
pubmed: 24934179
Brain Behav Immun. 2015 Jan;43:11-6
pubmed: 24937468
Biol Psychiatry. 2015 Jan 15;77(2):147-57
pubmed: 25034946
Mol Psychiatry. 2015 Feb;20(1):84-97
pubmed: 25048005
Psychoneuroendocrinology. 2014 Nov;49:187-206
pubmed: 25108162
J Child Neurol. 2015 May;30(6):749-56
pubmed: 25117419
JAMA Psychiatry. 2014 Oct;71(10):1121-8
pubmed: 25133871
J Immunol. 2014 Sep 15;193(6):2615-21
pubmed: 25193935
J Affect Disord. 2014 Dec;169:197-202
pubmed: 25212995
Mol Psychiatry. 2015 Sep;20(9):1108-19
pubmed: 25266124
Int J Tryptophan Res. 2014 Sep 16;7:15-22
pubmed: 25288889
Neural Plast. 2014;2014:360481
pubmed: 25313338
JAMA Psychiatry. 2014 Dec 1;71(12):1381-91
pubmed: 25322082
Front Cell Neurosci. 2014 Dec 04;8:419
pubmed: 25538568
Front Cell Neurosci. 2014 Dec 22;8:430
pubmed: 25565964
Cold Spring Harb Perspect Biol. 2015 Jan 29;7(5):null
pubmed: 25635046
JAMA Psychiatry. 2015 Apr;72(4):305-15
pubmed: 25651064
Brain Behav Immun. 2015 May;46:55-9
pubmed: 25686798
J Clin Psychiatry. 2015 Feb;76(2):142-50
pubmed: 25742201
Brain Behav Immun. 2015 Aug;48:48-52
pubmed: 25765557
J Psychiatry Neurosci. 2015 Jul;40(4):250-8
pubmed: 25768030
Br J Pharmacol. 2016 Feb;173(4):649-65
pubmed: 25800044
JAMA Psychiatry. 2015 Jun;72(6):527-8
pubmed: 25853989
BMC Med. 2015 Mar 19;13:55
pubmed: 25857826
Pharmacopsychiatry. 2015 Jul;48(4-5):136-40
pubmed: 25959196
Paediatr Perinat Epidemiol. 2015 Jul;29(4):307-16
pubmed: 25989831
J Clin Pharm Ther. 2015 Aug;40(4):441-6
pubmed: 26009929
Ann Pharmacother. 2015 Sep;49(9):953-61
pubmed: 26139640
Psychiatry Res. 2015 Sep 30;229(1-2):490-6
pubmed: 26144587
Mol Psychiatry. 2016 Apr;21(4):554-64
pubmed: 26169974
Psychiatry Res. 2015 Sep 30;229(1-2):27-36
pubmed: 26187338
Psychopharmacology (Berl). 2016 May;233(9):1575-89
pubmed: 26268146
Bipolar Disord. 2015 Sep;17(6):606-14
pubmed: 26291962
Iran J Pharm Res. 2015 Summer;14(3):891-9
pubmed: 26330878
Pharmacopsychiatry. 2015 Nov;48(7):268-73
pubmed: 26398281
Brain Behav Immun. 2016 Jul;55:105-113
pubmed: 26408795
Br J Pharmacol. 2016 Feb;173(4):666-80
pubmed: 26455353
Am J Psychiatry. 2016 Jan;173(1):44-52
pubmed: 26472628
Autism Res. 2016 Jun;9(6):621-31
pubmed: 26497015
BMC Med. 2015 Nov 30;13:289
pubmed: 26621529
Proc Biol Sci. 2015 Dec 22;282(1821):20143085
pubmed: 26702035
Nature. 2016 Feb 11;530(7589):177-83
pubmed: 26814963
Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jul 4;68:1-8
pubmed: 26903140
Mol Psychiatry. 2016 Dec;21(12):1696-1709
pubmed: 26903267
Front Cell Neurosci. 2016 Feb 12;10:21
pubmed: 26903806
J Neuroinflammation. 2016 Feb 29;13(1):51
pubmed: 26925576
Brain Behav Immun. 2016 Aug;56:352-62
pubmed: 26952745
Compr Physiol. 2016 Mar 15;6(2):603-21
pubmed: 27065163
Sci Rep. 2016 May 19;6:26105
pubmed: 27193331
Mol Psychiatry. 2016 Aug;21(8):1009-26
pubmed: 27271499
Brain Behav Immun. 2016 Nov;58:165-172
pubmed: 27287966
J Pharmacol Exp Ther. 2016 Sep;358(3):504-15
pubmed: 27384073
Mol Psychiatry. 2017 Nov;22(11):1576-1584
pubmed: 27400854
Psychiatry Clin Neurosci. 2016 Nov;70(11):517-526
pubmed: 27488081
Mediators Inflamm. 2016;2016:3476240
pubmed: 27524864
Science. 2016 Aug 19;353(6301):783-5
pubmed: 27540166
Am J Psychiatry. 2016 Sep 9;174(1):60-69
pubmed: 27609241
Curr Neuropharmacol. 2016;14(7):732-42
pubmed: 27640518
Neuropsychiatr Dis Treat. 2016 Dec 19;13:1-8
pubmed: 28031712
Front Syst Neurosci. 2016 Dec 27;10:104
pubmed: 28082874
Acta Psychiatr Scand. 2017 May;135(5):373-387
pubmed: 28122130
Schizophr Bull. 2017 Jul 1;43(4):764-777
pubmed: 28187219
BMC Psychiatry. 2017 Feb 14;17(1):70
pubmed: 28196529
Front Psychiatry. 2017 Feb 13;8:16
pubmed: 28243208
Brain Behav Immun. 2017 May;62:344-350
pubmed: 28257825
Transl Psychiatry. 2017 Mar 28;7(3):e1075
pubmed: 28350400
J Psychiatr Res. 2017 Sep;92:139-146
pubmed: 28445800
Front Syst Neurosci. 2017 Apr 27;11:25
pubmed: 28496402
Curr Neuropharmacol. 2017 Apr;15(3):359-371
pubmed: 28503107
Psychiatry Res. 2017 Sep;255:59-65
pubmed: 28528242
Dialogues Clin Neurosci. 2017 Mar;19(1):55-63
pubmed: 28566947
Can J Psychiatry. 2018 Jul;63(7):474-480
pubmed: 29108425
Aust N Z J Psychiatry. 2018 Oct;52(10):924-948
pubmed: 30231628
Early Interv Psychiatry. 2019 Oct;13(5):1032-1049
pubmed: 30690898
Br J Pharmacol. 1980 Nov;70(3):469-73
pubmed: 6108146
Nature. 1995 Nov 23;378(6555):406-9
pubmed: 7477380
J Immunol. 1995 Jul 15;155(2):796-801
pubmed: 7608556
J Clin Endocrinol Metab. 1995 Feb;80(2):517-23
pubmed: 7852513
J Psychiatr Res. 1994 May-Jun;28(3):239-65
pubmed: 7932285
J Clin Invest. 1994 Dec;94(6):2504-10
pubmed: 7989609
J Leukoc Biol. 1994 Apr;55(4):476-82
pubmed: 8145018
Am J Med. 1993 Aug 9;95(2A):40S-44S
pubmed: 8357002
J Biol Chem. 1993 Apr 25;268(12):9049-54
pubmed: 8473346
Cell. 1995 Nov 3;83(3):473-82
pubmed: 8521477
Schizophr Res. 1996 May;19(2-3):103-9
pubmed: 8789908
Trends Neurosci. 1996 Aug;19(8):312-8
pubmed: 8843599
Neuroimmunomodulation. 1995 Jul-Aug;2(4):241-8
pubmed: 8963753
J Neurosci. 1997 Apr 15;17(8):2746-55
pubmed: 9092596
J Neurocytol. 1997 Feb;26(2):77-82
pubmed: 9181482
Arterioscler Thromb Vasc Biol. 1997 Jun;17(6):1121-7
pubmed: 9194763
Schizophr Res. 1997 Aug 29;26(2-3):221-5
pubmed: 9323354
J Clin Invest. 1997 Dec 15;100(12):2941-7
pubmed: 9399938
Int J Dev Neurosci. 1997 Oct;15(6):711-6
pubmed: 9402221
Neuroscience. 1998 Mar;83(1):281-93
pubmed: 9466417
Lancet. 1998 Feb 28;351(9103):637-41
pubmed: 9500320
Exp Neurol. 1998 Feb;149(2):411-23
pubmed: 9500954
Ann N Y Acad Sci. 1998 May 1;840:123-7
pubmed: 9629244
J Affect Disord. 1998 Jun;49(3):211-9
pubmed: 9629951
Neurochem Int. 1998 Aug;33(2):143-54
pubmed: 9761458
Circulation. 1999 Jan 19;99(2):237-42
pubmed: 9892589