T Cells Are Dominant Population in Human Abdominal Aortic Aneurysms and Their Infiltration in the Perivascular Tissue Correlates With Disease Severity.
T cell
abdominal aortic aneurysm
inflammation
macrophages
perivascular adipose tissue
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
29
03
2019
accepted:
05
08
2019
entrez:
26
9
2019
pubmed:
26
9
2019
medline:
21
10
2020
Statut:
epublish
Résumé
Abdominal Aortic Aneurysm (AAA) is a major cause of cardiovascular mortality. Adverse changes in vascular phenotype act in concert with chronic inflammation to promote AAA progression. Perivascular adipose tissue (PVAT) helps maintain vascular homeostasis but when inflamed and dysfunctional, can also promote vascular pathology. Previous studies suggested that PVAT may be an important site of vascular inflammation in AAA; however, a detailed assessment of leukocyte populations in human AAA, their anatomic location in the vessel wall and correlation to AAA size remain undefined. Accordingly, we performed in depth immunophenotyping of cells infiltrating the pathologically altered perivascular tissue (PVT) and vessel wall in AAA samples at the site of maximal dilatation (
Identifiants
pubmed: 31552015
doi: 10.3389/fimmu.2019.01979
pmc: PMC6736986
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1979Subventions
Organisme : British Heart Foundation
ID : PG/12/81/29897
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/13/5/30177
Pays : United Kingdom
Références
Am J Pathol. 2002 Aug;161(2):499-506
pubmed: 12163375
Atherosclerosis. 2003 Sep;170(1):39-48
pubmed: 12957681
J Vasc Surg. 1992 Aug;16(2):139-47
pubmed: 1386635
J Immunol. 2004 Feb 15;172(4):2607-12
pubmed: 14764734
J Clin Invest. 2004 Jul;114(2):300-8
pubmed: 15254597
Arterioscler Thromb Vasc Biol. 2005 Jul;25(7):1347-52
pubmed: 15845908
Immunology. 2005 Jun;115(2):262-70
pubmed: 15885133
FASEB J. 2005 Sep;19(11):1528-30
pubmed: 16014397
Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2594-9
pubmed: 16195477
Clin Exp Immunol. 2005 Dec;142(3):519-27
pubmed: 16297165
Am J Pathol. 1990 Nov;137(5):1199-213
pubmed: 1700620
J Physiol Pharmacol. 2006 Dec;57(4):505-28
pubmed: 17229978
J Exp Med. 2007 Oct 1;204(10):2449-60
pubmed: 17875676
Clin Sci (Lond). 2008 Jun;114(11):687-97
pubmed: 18078385
J Physiol Pharmacol. 2007 Dec;58(4):591-610
pubmed: 18195475
Circ Res. 2008 Jun 6;102(11):1368-77
pubmed: 18451339
J Biol Chem. 2009 Jan 16;284(3):1765-71
pubmed: 19010778
Circulation. 2009 Apr 28;119(16):2209-16
pubmed: 19364980
N Engl J Med. 2009 Sep 10;361(11):1114-6
pubmed: 19741234
Pathobiology. 2009;76(5):243-52
pubmed: 19816084
Clin Sci (Lond). 2010 Mar 09;118(11):681-9
pubmed: 20088827
J Vasc Surg. 2010 Sep;52(3):539-48
pubmed: 20630687
Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2813-9
pubmed: 21960563
J Surg Res. 2012 Aug;176(2):672-8
pubmed: 22169593
Thromb Haemost. 2012 Nov;108(5):812-23
pubmed: 22955940
Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):431-8
pubmed: 23241402
Dis Markers. 2013;34(2):131-42
pubmed: 23348634
Int J Cardiol. 2013 Oct 3;168(3):2389-96
pubmed: 23506637
J Am Heart Assoc. 2013 Mar 08;2(2):e000065
pubmed: 23537804
J Immunol. 2013 May 15;190(10):5078-85
pubmed: 23585675
Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2374-9
pubmed: 23908246
J Vasc Surg. 2014 Jun;59(6):1512-7
pubmed: 24560865
PLoS One. 2014 Feb 27;9(2):e89983
pubmed: 24587165
Circulation. 2015 Feb 10;131(6):560-70
pubmed: 25552357
Cardiovasc Res. 2015 Jul 1;107(1):98-107
pubmed: 25824145
Arterioscler Thromb Vasc Biol. 2015 Aug;35(8):1746-55
pubmed: 26044582
FASEB J. 2016 May;30(5):1987-99
pubmed: 26873938
J Vasc Surg. 2017 Apr;65(4):1171-1179.e1
pubmed: 26960947
J Am Heart Assoc. 2016 Apr 28;5(5):
pubmed: 27126477
Eur Heart J. 2016 Aug 1;37(29):2315-2381
pubmed: 27222591
Front Immunol. 2016 Nov 07;7:481
pubmed: 27872626
J Obes. 2017;2017:3521649
pubmed: 28326193
Cardiovasc Res. 2017 Jul 1;113(9):1035-1045
pubmed: 28482008
Cardiovasc Res. 2017 Jul 1;113(9):1064-1073
pubmed: 28498891
Cardiovasc Res. 2017 Sep 1;113(11):1364-1375
pubmed: 28582477
Cardiovasc Res. 2017 Jul 1;113(9):999-1008
pubmed: 28582523
Cardiovasc Res. 2017 Jul 1;113(9):1055-1063
pubmed: 28838041
Cardiovasc Res. 2017 Jul 1;113(9):1009-1023
pubmed: 28838042
Cardiovasc Res. 2017 Jul 1;113(8):847-848
pubmed: 28863438
Cardiovasc Res. 2017 Oct 1;113(12):1441-1452
pubmed: 28957536
Cardiovasc Res. 2017 Nov 1;113(13):1664-1676
pubmed: 29048462
Clin Immunol. 2018 Sep;194:26-33
pubmed: 29936303
Lancet. 2018 Sep 15;392(10151):929-939
pubmed: 30170852
Mediators Inflamm. 2018 Dec 27;2018:6967310
pubmed: 30686933
Cardiovasc Res. 2019 Apr 13;:null
pubmed: 30980670
J Clin Invest. 1998 Dec 1;102(11):1900-10
pubmed: 9835614